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CAS 930856-19-2

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  • ERBB agonist-1
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    ERBB agonist-1

    CAS:
    <p>ERBB agonist-1 (Compound EF-1) is an ERBB4 agonist that activates the ERBB4 signaling pathway by inducing ERBB4 receptor dimerization, with an EC50 of 10.5 μM. It promotes phosphorylation of Akt and ERK1/2, reduces collagen expression in cardiac fibroblasts, and inhibits H2O2-induced cardiomyocyte death and Ang II-induced cardiac hypertrophy. Furthermore, ERBB agonist-1 can prevent myocardial fibrosis and demonstrates cardioprotective effects in mouse models.</p>
    Formula:C24H25N3O2S
    Color and Shape:Solid
    Molecular weight:419.539

    Ref: TM-T204401