CAS 93265-81-7

IPdR

Description:

IPdR, or 5-iodo-2'-deoxyuridine, is a nucleoside analog that has garnered interest primarily for its potential antiviral and anticancer properties. It is characterized by the presence of an iodine atom at the 5-position of the pyrimidine ring, which differentiates it from its parent compound, deoxyuridine. This modification can enhance its biological activity and alter its interaction with nucleic acid synthesis pathways. IPdR is known to inhibit viral replication, particularly in the context of certain DNA viruses, by interfering with the viral DNA polymerase. Additionally, its structural similarity to natural nucleosides allows it to be incorporated into DNA, potentially leading to cytotoxic effects in rapidly dividing cells, which is a desirable trait in cancer therapy. The compound is typically studied in the context of medicinal chemistry and pharmacology, where its efficacy and safety profiles are evaluated. As with many nucleoside analogs, the therapeutic applications of IPdR are accompanied by considerations regarding its metabolism and potential side effects.

Formula: C₉H₁₁IN₂O₄

InChI: InChI=1S/C9H11IN2O4/c10-5-2-11-9(15)12(3-5)8-1-6(14)7(4-13)16-8/h2-3,6-8,13-14H,1,4H2/t6-,7+,8+/m0/s1

InChI key: InChIKey=XIJXHOVKJAXCGJ-XLPZGREQSA-N

SMILES: O=C1N([C@@H]2O[C@H](CO)[C@@H](O)C2)C=C(I)C=N1

Synonyms:

• 1-(2-Deoxy-beta-ribofuranosyl)-5-iodo-2-pyrimidinone
• 1-(2-Deoxy-β-<span class="text-smallcaps">D</span>-erythro-pentofuranosyl)-5-iodo-2(1H)-pyrimidinone
• 1-(2-Deoxy-β-<span class="text-smallcaps">D</span>-ribofuranosyl)-5-iodo-2-pyrimidinone
• 1-(2-Deoxy-β-<span class="text-smallcaps">D</span>-ribofuranosyl)-5-iodo-2-pyrimidone
• 1-(2-deoxy-D-erythro-pentofuranosyl)-5-iodopyrimidin-2(1H)-one
• 2(1H)-Pyrimidinone, 1-(2-deoxy-β-<span class="text-smallcaps">D</span>-erythro-pentofuranosyl)-5-iodo-
• Ropidoxuridine
• IPdR
• 1-(2-Deoxy-β-D-erythro-pentofuranosyl)-5-iodo-2(1H)-pyrimidinone
• 2(1H)-Pyrimidinone, 1-(2-deoxy-β-D-erythro-pentofuranosyl)-5-iodo-
• 1-(2-Deoxy-β-D-ribofuranosyl)-5-iodo-2-pyrimidinone

Ropidoxuridine

CAS: 93265-81-7

Ropidoxuridine (IPdR), a novel oral prodrug, is a halogenated thymidine analogue that may sensitize human tumors.

Formula: C₉H₁₁IN₂O₄

Purity: 97.07%

Color and Shape: Solid

Molecular weight: 338.1

Ref: TM-T16785

Ropidoxuridine

CAS: 93265-81-7

Ropidoxuridine

Purity: ≥98%

Molecular weight: 338.1g/mol

Ref: 54-BUP09153

Ropidoxuridine

Controlled Product

CAS: 93265-81-7

Formula: C₉H₁₁IN₂O₄

Color and Shape: Neat

Molecular weight: 338.099

Ref: TR-R640700