CAS 93390-81-9: Fosphenytoin

Description: Fosphenytoin is a prodrug of phenytoin, primarily used in the treatment of seizures, particularly in emergency settings. It is characterized by its water-soluble phosphate ester form, which allows for intravenous administration, making it advantageous for rapid control of seizures. Upon administration, it is converted to phenytoin in the body, exerting its anticonvulsant effects. Fosphenytoin is typically administered as a sodium salt and is known for its ability to minimize the risk of phlebitis associated with intravenous phenytoin. The compound has a molecular formula that reflects its complex structure, incorporating phosphorus and multiple functional groups that contribute to its solubility and pharmacokinetic properties. Its mechanism of action involves the stabilization of neuronal membranes and modulation of ion channels, particularly sodium channels, which helps to prevent the spread of seizure activity in the brain. As with any medication, it is essential to monitor for potential side effects, including allergic reactions and cardiovascular effects, particularly during rapid infusion.

Formula: C₁₆H₁₅N₂O₆P

InChI: InChI=1S/C16H15N2O6P/c19-14-16(12-7-3-1-4-8-12,13-9-5-2-6-10-13)17-15(20)18(14)11-24-25(21,22)23/h1-10H,11H2,(H,17,20)(H2,21,22,23)

InChI key: InChIKey=XWLUWCNOOVRFPX-UHFFFAOYSA-N

SMILES: O=C1NC(C(=O)N1COP(=O)(O)O)(C=2C=CC=CC2)C=3C=CC=CC3

Synonyms:

• Cerebyx
• (3-Phosphoryloxymethyl)phenytoin
• 5,5-Diphenyl-3-[(phosphonooxy)methyl]-2,4-imidazolidinedione
• Fosphenytoin
• 2,4-Imidazolidinedione, 5,5-diphenyl-3-[(phosphonooxy)methyl]-

Fosphenytoin

CAS: 93390-81-9

• Purity: ≥98%
• Molecular weight: 362.27g/mol

Fosphenytoin Sodium-d10

CAS: 92134-98-0 93390-81-9

• Formula: C₁₆D₁₀H₃N₂O₆P·Na₂
• Color and Shape: Neat
• Molecular weight: 416.3

Fosphenytoin

CAS: 93390-81-9

Fosphenytoin, a prodrug, is hydrolyzed to phenytoin for acute seizure intervention; given intravenously or intraperitoneally.

• Formula: C₁₆H₁₅N₂O₆P
• Purity: 100%
• Color and Shape: Solid
• Molecular weight: 362.27