CAS 934743-11-0

1,2,3,4-Tetrahydro-α-hydroxy-2,4-dioxo-1-β-D-ribofuranosyl-5-pyrimidineacetic acid

Description:

1,2,3,4-Tetrahydro-α-hydroxy-2,4-dioxo-1-β-D-ribofuranosyl-5-pyrimidineacetic acid, with the CAS number 934743-11-0, is a chemical compound that features a complex structure incorporating both a ribofuranosyl moiety and a pyrimidineacetic acid component. This compound is characterized by its tetrahydro structure, which indicates the presence of a saturated cyclic system, and the presence of hydroxyl and dicarbonyl functional groups, contributing to its reactivity and potential biological activity. The ribofuranosyl part suggests that it may have nucleoside-like properties, which could be relevant in biochemical contexts, particularly in relation to nucleic acid metabolism or as a potential therapeutic agent. The compound's specific stereochemistry and functional groups may influence its solubility, stability, and interactions with biological targets. Overall, this compound represents a unique blend of features that could be of interest in medicinal chemistry and biochemistry research.

Formula: C₁₁H₁₄N₂O₉

InChI: InChI=1S/C11H14N2O9/c14-2-4-6(16)7(17)9(22-4)13-1-3(5(15)10(19)20)8(18)12-11(13)21/h1,4-7,9,14-17H,2H2,(H,19,20)(H,12,18,21)/t4-,5?,6-,7-,9-/m1/s1

InChI key: InChIKey=UVGCZRPOXXYZKH-QADQDURISA-N

SMILES: O=C1N(C=C(C(C(O)=O)O)C(=O)N1)[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O

Synonyms:

• 5-Carboxyhydroxymethyl-uridine
• 1,2,3,4-Tetrahydro-α-hydroxy-2,4-dioxo-1-β-D-ribofuranosyl-5-pyrimidineacetic acid
• 5-Pyrimidineacetic acid, 1,2,3,4-tetrahydro-α-hydroxy-2,4-dioxo-1-β-D-ribofuranosyl-
• 5-(2-HO-carboxymethyl) uridine

5-Carboxyhydroxymethyluridine

CAS: 934743-11-0

5-Carboxyhydroxymethyluridine is a hydroxylated nucleoside that is used to study DNA repair. It is a nucleotide analogue that has been modified at the hydroxyl group by methylation. 5-Carboxyhydroxymethyluridine can be converted back to uridine by escherichia coli hydroxylases, but this conversion does not occur in vivo. 5-Carboxyhydroxymethyluridine can be used as a substrate for methyltransferase enzymes, which are involved in DNA repair. The enzyme 5'-methylthioadenosine phosphorylase converts 5-carboxyhydroxymethyluridine into S-adenosylhomocysteine and adenine. This conversion can be reversed by the enzyme methionine synthase. Some homologues of 5-carboxyhydroxymethyluridine have been found in nature and other modifications have been made on the

Formula: C₁₁H₁₄N₂O₉

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 318.24 g/mol

Ref: 3D-NC159485

5-Carboxyhydroxymethyluridine

Controlled Product

CAS: 934743-11-0

Applications 5-Carboxyhydroxymethyluridine is a naturally occuring modified nucleoside in RNA that assists in RNA stability, folding and other functions.
References Aduri, R., et al.: J. Chem. Theory Comput., 3, 1464 (2007); Xu, Y., et al.: J. Comput. Chem., 37, 896 (2016)

Formula: C₁₁H₁₄N₂O₉

Color and Shape: Neat

Molecular weight: 318.237

Ref: TR-C176450