CAS 935666-88-9
:AZD-1480
Description:
AZD-1480, with the CAS number 935666-88-9, is a small molecule inhibitor primarily known for its role in targeting Janus kinase (JAK) pathways, particularly JAK2. This compound has garnered attention in the field of pharmacology for its potential therapeutic applications, especially in the treatment of various inflammatory and autoimmune diseases, as well as certain types of cancer. AZD-1480 exhibits characteristics typical of kinase inhibitors, including the ability to modulate signaling pathways involved in cell proliferation and survival. Its mechanism of action involves the selective inhibition of JAK2, which plays a crucial role in the signaling of several cytokines and growth factors. In preclinical studies, AZD-1480 has demonstrated efficacy in reducing inflammation and tumor growth, making it a candidate for further clinical investigation. However, like many investigational drugs, its safety profile, pharmacokinetics, and long-term effects are subjects of ongoing research. Overall, AZD-1480 represents a promising avenue in targeted therapy, particularly in conditions driven by dysregulated JAK signaling.
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Found 6 products.
AZD-1480
CAS:<p>AZD1480: JAK2 inhibitor, IC50 0.26 nM; selective vs Tyk2, JAK3; less on JAK1. Used in solid tumors, PPV, PMF, ET trials.</p>Formula:C14H14ClFN8Purity:98.25% - 99.47%Color and Shape:SolidMolecular weight:348.77AZD 1480
CAS:Controlled Product<p>Applications AZD 1480 is an inhibitor of the Jak/Stat Pathway. Potent JAK2 inhibitor.<br>References Ioannidis, S., et al.: J. Med. Chem., 54, 262 (2011); Xin, H., et al.: Cancer Res., 71, 6610 (2011);<br></p>Formula:C14H14ClFN8Color and Shape:NeatMolecular weight:348.77
