CAS 935840-35-0

trans-3-Fluoro-3-[3-fluoro-4-(1-pyrrolidinylmethyl)phenyl]-N-(2-methylpropyl)cyclobutanecarboxamide

Description:

Trans-3-Fluoro-3-[3-fluoro-4-(1-pyrrolidinylmethyl)phenyl]-N-(2-methylpropyl)cyclobutanecarboxamide is a synthetic organic compound characterized by its complex structure, which includes a cyclobutane ring, multiple fluorine substituents, and a pyrrolidine moiety. The presence of fluorine atoms typically enhances the compound's lipophilicity and metabolic stability, making it of interest in medicinal chemistry, particularly in the development of pharmaceuticals. The cyclobutane ring contributes to the rigidity of the molecule, potentially influencing its biological activity and interaction with target proteins. The amide functional group is known for its ability to form hydrogen bonds, which can be crucial for binding affinity in biological systems. Additionally, the presence of a branched alkyl chain (2-methylpropyl) may affect the compound's pharmacokinetics, including absorption and distribution. Overall, this compound's unique structural features suggest potential applications in drug development, particularly in areas targeting specific receptors or enzymes. However, detailed studies would be necessary to fully elucidate its properties and biological effects.

Formula: C₂₀H₂₈F₂N₂O

InChI: InChI=1/C20H28F2N2O/c1-14(2)12-23-19(25)16-10-20(22,11-16)17-6-5-15(18(21)9-17)13-24-7-3-4-8-24/h5-6,9,14,16H,3-4,7-8,10-13H2,1-2H3,(H,23,25)/t16-,20-

InChI key: InChIKey=DJRDLCHHQYHQQK-UKIBZPOANA-N

SMILES: F[C@@]1(C[C@@H](C(NCC(C)C)=O)C1)C2=CC(F)=C(CN3CCCC3)C=C2

Synonyms:

• trans-3-Fluoro-3-[3-fluoro-4-(1-pyrrolidinylmethyl)phenyl]-N-(2-methylpropyl)cyclobutanecarboxamide
• PF 03654764
• Cyclobutanecarboxamide, 3-fluoro-3-[3-fluoro-4-(1-pyrrolidinylmethyl)phenyl]-N-(2-methylpropyl)-, trans-

FPFT-2216

CAS: 935840-35-0

FPFT-2216

Purity: ≥98%

Molecular weight: 292.31g/mol

Ref: 54-BUP20480

3-Fluoro-3-(3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl)-N-(2-methylpropyl)cyclobutanecarboxamide

CAS: 935840-35-0

3-Fluoro-3-(3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl)-N-(2-methylpropyl)cyclobutanecarboxamide is a peptide that activates the ion channel TRPV1. It is an agonist for this receptor and has been shown to induce pain in animals. The structure of 3-fluoro-3-(3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl)-N-(2-methylpropyl)cyclobutanecarboxamide is shown in Figure 1.

Formula: C₂₀H₂₈F₂N₂O

Purity: Min. 95%

Molecular weight: 350.4 g/mol

Ref: 3D-KMB84035

PF-03654764

CAS: 935840-35-0

PF-03654764, an oral H3 receptor blocker, Ki: human 1.2 nM, rat 7.9 nM, used with Fexofenadine for allergic rhinitis.

Formula: C₂₀H₂₈F₂N₂O

Purity: >99.99%

Color and Shape: Solid

Molecular weight: 350.45

Ref: TM-T61213