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CAS 936623-90-4

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Sacubitril-valsartan

Description:
Sacubitril-valsartan is a combination medication primarily used in the treatment of heart failure with reduced ejection fraction. It consists of two active components: sacubitril, a neprilysin inhibitor that enhances the levels of natriuretic peptides, and valsartan, an angiotensin II receptor blocker (ARB) that helps to lower blood pressure and reduce strain on the heart. The mechanism of action involves the dual inhibition of the renin-angiotensin-aldosterone system (RAAS) and the neprilysin pathway, leading to vasodilation, reduced blood volume, and improved cardiac output. Sacubitril-valsartan is typically administered orally and is known for its favorable effects on morbidity and mortality in heart failure patients. Common side effects may include hypotension, hyperkalemia, and renal impairment. The drug is contraindicated in patients with a history of angioedema related to previous ACE inhibitor or ARB therapy. Overall, sacubitril-valsartan represents a significant advancement in heart failure management, offering a novel therapeutic approach to improve patient outcomes.
Formula:(C24H29N5O3)·2(C24H29NO5)·5(H2O)·6Na
InChI:InChI=1S/C24H29N5O3.C24H29NO5.Na.H2O/c1-4-5-10-21(30)29(22(16(2)3)24(31)32)15-17-11-13-18(14-12-17)19-8-6-7-9-20(19)23-25-27-28-26-23;1-3-30-24(29)17(2)15-21(25-22(26)13-14-23(27)28)16-18-9-11-20(12-10-18)19-7-5-4-6-8-19;;/h6-9,11-14,16,22H,4-5,10,15H2,1-3H3,(H,31,32)(H,25,26,27,28);4-12,17,21H,3,13-16H2,1-2H3,(H,25,26)(H,27,28);;1H2/t22-;17-,21+;;/m01../s1
InChI key:InChIKey=IFCNUAFRAJCYKN-DDXUJOENSA-N
SMILES:C([C@H](C[C@H](C(OCC)=O)C)NC(CCC(O)=O)=O)C1=CC=C(C=C1)C2=CC=CC=C2.C(N([C@@H]([C@H](C)C)C(O)=O)C(CCCC)=O)C1=CC=C(C2=C(C=CC=C2)C=3NN=NN3)C=C1.[Na].O
Synonyms:
  • <span class="text-smallcaps">L</span>-Valine, N-(1-oxopentyl)-N-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-, compd. with α-ethyl (αR,γS)-γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl[1,1′-biphenyl]-4-pentanoate, sodium salt, hydrate (2:2:6:5)
  • Entresto
  • L-Valine, N-(1-oxopentyl)-N-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, compd. with α-ethyl (αR,γS)-γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl[1,1'-biphenyl]-4-pentanoate, sodium salt, hydrate (2:2:6:5)
  • Lcz 696
  • Neparvis
  • Sacubitril mixture with Valsartan
  • Sacubitril-valsartan mixt.
  • Sacubitril/Valsartan
  • Valsartan-Sacubitril sodium
  • Valsartan/Sacubitril 3Na-2.5 H2O
  • See more synonyms
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