CAS 937174-76-0

GSK 690693

Description:

GSK 690693 is a small molecule inhibitor primarily known for its role as a selective inhibitor of the protein kinase AKT (also known as protein kinase B). It is part of a class of compounds that target signaling pathways involved in cell growth, survival, and metabolism, making it of interest in cancer research and therapy. The compound exhibits a specific affinity for the AKT isoforms, which play crucial roles in various cellular processes, including apoptosis and glucose metabolism. GSK 690693 has been studied for its potential therapeutic applications in various malignancies, particularly those characterized by aberrant AKT signaling. In terms of its chemical properties, GSK 690693 is characterized by its molecular structure, which includes specific functional groups that contribute to its biological activity and selectivity. As with many kinase inhibitors, its efficacy and safety profile are subjects of ongoing research, particularly in the context of combination therapies and resistance mechanisms in cancer treatment.

Formula: C₂₁H₂₇N₇O₃

InChI: InChI=1S/C21H27N7O3/c1-4-28-18-15(30-12-13-6-5-9-23-10-13)11-24-14(7-8-21(2,3)29)16(18)25-20(28)17-19(22)27-31-26-17/h11,13,23,29H,4-6,9-10,12H2,1-3H3,(H2,22,27)/t13-/m0/s1

InChI key: InChIKey=KGPGFQWBCSZGEL-ZDUSSCGKSA-N

SMILES: C(C)N1C=2C(=C(C#CC(C)(C)O)N=CC2OC[C@H]3CCCNC3)N=C1C=4C(N)=NON4

Synonyms:

• 3-Butyn-2-ol, 4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-
• Gsk 690693
• Gsk690693
• 4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-3-butyn-2-ol

Gsk 690693

CAS: 937174-76-0

Gsk 690693

Purity: 99%

Molecular weight: 425.48g/mol

Ref: 54-OR1023327

GSK-690693

CAS: 937174-76-0

GSK-690693

Purity: ≥95%

Molecular weight: 425.48g/mol

Ref: 54-BUP09587

GSK690693

CAS: 937174-76-0

Ref: 7W-GW3442

GSK690693

CAS: 937174-76-0

Formula: C₂₁H₂₇N₇O₃

Molecular weight: 425.49

Ref: 4Z-K-031001

GSK-690693

CAS: 937174-76-0

GSK-690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. Phase 1.

Formula: C₂₁H₂₇N₇O₃

Purity: 98.07% - 99.77%

Color and Shape: Solid

Molecular weight: 425.48

Ref: TM-T6285

GSK690693

CAS: 937174-76-0

GSK690693 is a small-molecule inhibitor of ATP binding cassette (ABC) transporters. This class of transporter proteins is responsible for transporting a variety of substrates, including chemotherapeutic drugs, into and out of cells. GSK690693 has been shown to inhibit the ABC transporter P-glycoprotein (Pgp), which is an important drug efflux pump that may be involved in resistance to chemotherapeutics such as vinca alkaloids, anthracyclines, taxanes, and many other anticancer agents. GSK690693 also inhibits the ABC transporter Bcrp1, which transports a number of drugs and xenobiotics out of cells. GSK690693 was shown to synergize with anticancer agents in vitro by increasing the sensitivity of cancer cells to these agents.

Formula: C₂₁H₂₇N₇O₃

Purity: Min. 95%

Molecular weight: 425.48 g/mol

Ref: 3D-BG174974