CAS 937738-64-2

17(R)-Resolvin d1 methyl ester

CAS: 937738-64-2

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Formula: C₂₃H₃₄O₅

Purity: Min. 95%

Molecular weight: 390.5 g/mol

Ref: 3D-MMB73864

17(R)-Resolvin D1 methyl ester

CAS: 937738-64-2

17(R)-Resolvin D1 (17(R)-RvD1) is an aspirin-triggered epimer of RvD1 that equivalently inhibits human polymorphonuclear leukocyte migration across the endothelium (EC50= ~30 nM), a precursor to acute inflammation. Unlike RvD1, it resists rapid degradation by eicosanoid oxidoreductases. In a mouse peritonitis model, 17(R)-RvD1 dose-dependently reduces leukocyte infiltration, achieving up to a 35% decrease with a 100 ng dose. Additionally, its methyl ester derivative, designed to enhance its pharmacokinetic and distribution properties as a more lipophilic prodrug, can be converted back into the active acid form by intracellular esterases.

Formula: C₂₃H₃₄O₅

Color and Shape: Solid

Molecular weight: 390.5

Ref: TM-T84455