CAS 938-94-3

2-(p-Tolyl)propionic acid

Description:

2-(p-Tolyl)propionic acid, also known as ibuprofen, is a nonsteroidal anti-inflammatory drug (NSAID) commonly used for its analgesic, antipyretic, and anti-inflammatory properties. It is characterized by its propionic acid structure, which includes a propyl group attached to a phenyl ring substituted with a para-methyl group (p-tolyl). This compound is typically a white to off-white crystalline solid with a melting point that allows it to be easily formulated into various pharmaceutical forms, such as tablets and suspensions. It is soluble in organic solvents like ethanol and slightly soluble in water, which influences its bioavailability. The mechanism of action involves the inhibition of cyclooxygenase (COX) enzymes, leading to a decrease in the synthesis of prostaglandins, thereby reducing pain and inflammation. Due to its widespread use, 2-(p-Tolyl)propionic acid has a well-established safety profile, although it can cause gastrointestinal side effects and should be used with caution in certain populations.

Formula: C₁₀H₁₁O₂

InChI: InChI=1/C10H12O2/c1-7-3-5-9(6-4-7)8(2)10(11)12/h3-6,8H,1-2H3,(H,11,12)/p-1/t8-/m0/s1

SMILES: Cc1ccc(cc1)[C@H](C)C(=O)[O-]

Synonyms:

• 2-(4-Methylphenyl) propionic acid
• Ibuprofen Imp D
• Ibuprofen Impurity D
• 4-Methyl-2-Phenylpropionic Acid
• Alpha,4-Dimethylphenylacetic Acid
• 2-(4-Methylphenyl)Propanoic Acid
• (2Rs)-2-(4-Methylphenyl)Propanoic Acid
• (2R)-2-(4-methylphenyl)propanoate
• (2S)-2-(4-methylphenyl)propanoate

2-(4-Methylphenyl)propanoic acid

CAS: 938-94-3

Formula: C₁₀H₁₂O₂

Purity: 97%

Color and Shape: Solid

Molecular weight: 164.2011

Ref: IN-DA003EX6

α,4-Dimethylphenylacetic acid

CAS: 938-94-3

Formula: CH₃C₆H₄CH(CH₃)CO₂H

Purity: ≥ 98.0%

Color and Shape: White to yellow solid or liquid

Molecular weight: 164.20

Ref: 7W-GL0919

2-(p-Tolyl)propanoic acid

CAS: 938-94-3

2-(p-Tolyl)propanoic acid

Purity: 97%

Molecular weight: 164.20g/mol

Ref: 54-OR95467

Ibuprofen EP Impurity D

CAS: 938-94-3

Formula: C₁₀H₁₂O₂

Color and Shape: White To Off-White Solid

Molecular weight: 164.20

Ref: 4Z-I-0410

(2RS)-2-(4-Methylphenyl)propanoic Acid

Controlled Product

CAS: 938-94-3

Formula: C₁₀H₁₂O₂

Color and Shape: Neat

Molecular weight: 164.20

Ref: 86-MM0002.11

2-(p-Tolyl)propionic Acid

Controlled Product

CAS: 938-94-3

Impurity Ibuprofen EP Impurity D
Applications 2-(p-Tolyl)propionic acid (Ibuprofen EP Impurity D) is an impurity of Ibuprofen (I140000). Ibuprofen impurity D.
References Jia, C., et al.: Science, 287, 1992 (2000), Yu, J., et al.: Org. Biomol. Chem., 4, 4041 (2006),

Formula: C₁₀H₁₂O₂

Color and Shape: White To Off-White

Molecular weight: 164.20

Ref: TR-T536780

Ibuprofen EP Impurity D

CAS: 938-94-3

Formula: C₁₀H₁₂O₂

Molecular weight: 164.20

Ref: ST-EA-CP-I2004

2-(p-Tolyl)propionic acid

CAS: 938-94-3

2-(p-Tolyl)propionic acid is a bromic chemical compound that binds to the 5-HT4 receptor. It is used in the treatment of chronic pain and osteoarthritis, as well as for the management of acute pain following surgery. 2-(p-Tolyl)propionic acid has been shown to be more potent than other drugs in its class and has a low incidence of side effects. This drug can be administered via oral, parenteral, or topical routes with equal efficacy. 2-(p-Tolyl)propionic acid is metabolized by cytochrome P450 enzymes in the liver to form p-hydroxybenzoic acid, which is excreted in urine. The drug also blocks chloride channels and potassium ion channels, inhibiting cellular depolarization and leading to inhibition of pain.

Formula: C₁₀H₁₂O₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 164.20 g/mol

Ref: 3D-FT28321

2-(4-Methylphenyl)propanoic acid

CAS: 938-94-3

Formula: C₁₀H₁₂O₂

Purity: 97%

Color and Shape: Solid

Molecular weight: 164.204

Ref: 10-F065857