CAS 94088-00-3
:Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-21-(phosphonooxy)-, sodium salt (1:2), (11β)-
Description:
Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-21-(phosphonooxy)-, sodium salt (1:2), (11β)-, commonly referred to by its CAS number 94088-00-3, is a synthetic corticosteroid with anti-inflammatory and immunosuppressive properties. This compound is characterized by its steroidal structure, which includes a fluorine atom and hydroxyl groups that enhance its biological activity. The presence of a phosphonooxy group contributes to its solubility and stability in aqueous solutions, making it suitable for pharmaceutical formulations. As a sodium salt, it is often used to improve the compound's bioavailability and facilitate its administration. The compound is typically utilized in various therapeutic applications, particularly in treating conditions that require modulation of the immune response or reduction of inflammation. Its pharmacological effects are mediated through interaction with glucocorticoid receptors, influencing gene expression and cellular responses. Overall, this compound exemplifies the structural modifications that enhance the efficacy and safety profile of corticosteroids in clinical use.
Formula:C21H26FNa2O8P
InChI:InChI=1/C21H28FO8P.2Na/c1-18-7-5-13(23)9-12(18)3-4-15-14-6-8-20(26,17(25)11-30-31(27,28)29)19(14,2)10-16(24)21(15,18)22;;/h5,7,9,14-16,24,26H,3-4,6,8,10-11H2,1-2H3,(H2,27,28,29);;/q;2*+1/t14-,15-,16-,18-,19-,20-,21-;;/m0../s1
InChI key:InChIKey=TZGWKUILYNXKBG-VJVYSMTMSA-N
SMILES:F[C@@]12[C@]([C@]3([C@](C)(C[C@@H]1O)[C@](C(COP(=O)(O)O)=O)(O)CC3)[H])(CCC=4[C@]2(C)C=CC(=O)C4)[H].[Na]
Synonyms:- Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-21-(phosphonooxy)-, disodium salt, (11beta)-
- Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-21-(phosphonooxy)-, sodium salt (1:2), (11β)-
- disodium [2-[(8S,9R,10S,11S,13S,14S,17R)-9-fluoro-11,17-dihydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] dihydrogen phosphate
- Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-21-(phosphonooxy)-, disodium salt, (11β)-
- Isoflupredone Disodium Phosphate
- 9-Fluoro-3,20-dioxopregna-1,4-diene-11β,17,21-triol 21-[phosphoric acid disodium] salt
- Sodium 2-((8S,9R,10S,11S,13S,14S,17R)-9-fluoro-11,17-dihydroxy-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl phosphate
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Found 3 products.
Isoflupredone 21-Phosphate Ester Disodium Salt
CAS:<p>Stability Hygroscopic, Temperature Sensitive<br>Applications Isoflupredone 21-Phosphate Ester Disodium Salt is a derivative of Isofluopredone (I816600), an anti-inflammatory similar to Betamethasone (B327000).<br>References Ferrante, M.G., et al.: Anal. Profiles Drug Subs., 6, 43 (1977), Li, A., et al.: Chem. Biol. Interact., 142, 7 (2002), Cruz-Monteagudo, M., et al.: Eur. J. Med. Chem., 40, 1030 (2005), Rothfuss, A., et al.: Chem. Res. Toxicol., 19, 1313 (2006); Buchwald, P., et al.: Steroids, 73, 193 (2008), Holbeck, S., et al.: Mol. Endocrinol., 24, 1287 (2010),<br></p>Formula:C21H26FNa2O8PColor and Shape:NeatMolecular weight:502.38
