CAS 940908-79-2: Mericitabine

Description: Mericitabine, also known by its developmental code name, is a nucleoside analog with antiviral properties, primarily investigated for the treatment of hepatitis C virus (HCV) infections. It functions by inhibiting viral replication through its incorporation into viral RNA, leading to premature termination of the RNA chain. Mericitabine is characterized by its structural similarity to natural nucleosides, which allows it to effectively compete with them during the viral replication process. The compound exhibits a favorable pharmacokinetic profile, including good oral bioavailability and a manageable safety profile, making it a candidate for combination therapies. Its mechanism of action, along with its ability to target specific viral strains, positions Mericitabine as a potential therapeutic option in the evolving landscape of antiviral treatments. Ongoing research continues to evaluate its efficacy and safety in various patient populations, contributing to the broader understanding of antiviral drug development.

Formula: C₁₈H₂₆FN₃O₆

InChI: InChI=1S/C18H26FN3O6/c1-9(2)14(23)26-8-11-13(28-15(24)10(3)4)18(5,19)16(27-11)22-7-6-12(20)21-17(22)25/h6-7,9-11,13,16H,8H2,1-5H3,(H2,20,21,25)/t11-,13-,16-,18-/m1/s1

InChI key: InChIKey=MLESJYFEMSJZLZ-MAAOGQSESA-N

SMILES: O=C1N=C(N)C=CN1C2OC(COC(=O)C(C)C)C(OC(=O)C(C)C)C2(F)C

Synonyms:

• 2′-Deoxy-2′-fluoro-2′-C-methylcytidine diisobutyrate
• 2′α-Fluoro-2′β-methyl-3′,5′-diisobutyryldeoxycytidine
• 3′,5′-Diisobutyryl PSI 6130
• Cytidine, 2′-deoxy-2′-fluoro-2′-methyl-, 3′,5′-bis(2-methylpropanoate), (2′R)-
• Mericitabine
• PSI 6130 diisobutyrate
• R-7128
• Rg 7128
• Ro-5024048

(2'R)- 2'-Deoxy-2'-fluoro-2'-methylcytidine 3',5'-bis(2-methylpropanoate)

CAS: 940908-79-2

• Formula: C₁₈H₂₆FN₃O₆
• Purity: 98%
• Molecular weight: 399.4139

Mericitabine

CAS: 940908-79-2

• Purity: ≥98%
• Molecular weight: 399.41g/mol

Mericitabine

CAS: 940908-79-2

Mericitabine (R-7128) is an HCV inhibitor that terminates RNA chains, halting replication.

• Formula: C₁₈H₂₆FN₃O₆
• Purity: 97.77% - 98.1%
• Color and Shape: Solid
• Molecular weight: 399.41

R 7128

CAS: 940908-79-2

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• Formula: C₁₈H₂₆FN₃O₆
• Purity: Min. 95%
• Molecular weight: 399.41 g/mol