CAS 940908-79-2

Mericitabine

Description:

Mericitabine, also known by its developmental code name, is a nucleoside analog with antiviral properties, primarily investigated for the treatment of hepatitis C virus (HCV) infections. It functions by inhibiting viral replication through its incorporation into viral RNA, leading to premature termination of the RNA chain. Mericitabine is characterized by its structural similarity to natural nucleosides, which allows it to effectively compete with them during the viral replication process. The compound exhibits a favorable pharmacokinetic profile, including good oral bioavailability and a manageable safety profile, making it a candidate for combination therapies. Its mechanism of action, along with its ability to target specific viral strains, positions Mericitabine as a potential therapeutic option in the evolving landscape of antiviral treatments. Ongoing research continues to evaluate its efficacy and safety in various patient populations, contributing to the broader understanding of antiviral drug development.

Formula: C₁₈H₂₆FN₃O₆

InChI: InChI=1S/C18H26FN3O6/c1-9(2)14(23)26-8-11-13(28-15(24)10(3)4)18(5,19)16(27-11)22-7-6-12(20)21-17(22)25/h6-7,9-11,13,16H,8H2,1-5H3,(H2,20,21,25)/t11-,13-,16-,18-/m1/s1

InChI key: InChIKey=MLESJYFEMSJZLZ-MAAOGQSESA-N

SMILES: C[C@]1(F)[C@@H](O[C@H](COC(C(C)C)=O)[C@H]1OC(C(C)C)=O)N2C(=O)N=C(N)C=C2

Synonyms:

• 2′-Deoxy-2′-fluoro-2′-C-methylcytidine diisobutyrate
• 2′α-Fluoro-2′β-methyl-3′,5′-diisobutyryldeoxycytidine
• 3′,5′-Diisobutyryl PSI 6130
• Cytidine, 2′-deoxy-2′-fluoro-2′-methyl-, 3′,5′-bis(2-methylpropanoate), (2′R)-
• Mericitabine
• PSI 6130 diisobutyrate
• R-7128
• Rg 7128
• Ro-5024048
• RG 7128; MERICITABINE; PSI 6130 DIISOBUTYRATE
• Mericitabine，R-7128
• R-7128(Mericitabine)
• (2'R)- 2'-Deoxy-2'-fluoro-2'-methylcytidine 3',5'-bis(2-methylpropanoate)
• Mericitabine/RG7128

R7128

CAS: 940908-79-2

Formula: C₁₈H₂₆FN₃O₆

Purity: 97%

Molecular weight: 399.4139

Ref: IN-DA00GU5Y

Mericitabine

CAS: 940908-79-2

Mericitabine

Purity: ≥95%

Molecular weight: 399.41g/mol

Ref: 54-BUP15287

Mericitabine

CAS: 940908-79-2

Mericitabine (R-7128) is an HCV inhibitor that terminates RNA chains, halting replication.

Formula: C₁₈H₂₆FN₃O₆

Purity: 97.77% - 98.54%

Color and Shape: Solid

Molecular weight: 399.41

Ref: TM-T16710

R 7128

CAS: 940908-79-2

R 7128 is a potent inhibitor of HIV-1 protease. It has been shown to inhibit viral replication in tissue culture and primary cells infected with HIV-1. R 7128 may also be an effective therapeutic agent for the treatment of hepatitis B or C because it inhibits the production of virions and reduces the number of infected cells. This drug is a prodrug that is orally active and must undergo metabolism before becoming active. The mechanism of action for R 7128 is not yet known, but it may be due to its ability to inhibit viral life cycle stages, such as protease activity or protein synthesis.

Formula: C₁₈H₂₆FN₃O₆

Purity: Min. 95%

Molecular weight: 399.41 g/mol

Ref: 3D-FR102676