CAS 941678-49-5: Ruxolitinib

Formula: C₁₇H₁₈N₆

InChI: InChI=1S/C17H18N6/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16/h6,8-12,15H,1-5H2,(H,19,20,21)/t15-/m1/s1

InChI key: InChIKey=HFNKQEVNSGCOJV-OAHLLOKOSA-N

SMILES: N#CCC(N1N=CC(=C1)C=2N=CN=C3NC=CC32)C4CCCC4

Synonyms:

• (3R)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile
• (Betar)-Beta-Cyclopentyl-4-(7H-Pyrrolo(2,3-D)Pyrimidin-4-Yl)-1H-Pyrazole-1-Propanenitrile
• (R)-3-[4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-cyclopentylpropanenitrile
• (βR)-β-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile
• 1H-Pyrazole-1-propanenitrile, β-cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-, (βR)-
• Inc 424
• Incb-018424
• R-Incb018424
• R-Ruxolitinib
• Ruxolitinib (INCB 018424)
• Ruxolitinib phosphate salt

Ruxolitinib

CAS: 941678-49-5

• Formula: C₁₇H₁₈N₆
• Color and Shape: White To Off-White Solid
• Molecular weight: 306.37

Ruxolitinib

CAS: 941678-49-5

• Formula: C₁₇H₁₈N₆
• Purity: 98% (Typical Value in Batch COA)
• Color and Shape: white solid
• Molecular weight: 306.37g/mol

Ruxolitinib

CAS: 941678-49-5

• Formula: C₁₇H₁₈N₆
• Color and Shape: Neat
• Molecular weight: 306.36

Ruxolitinib

CAS: 941678-49-5

Ruxolitinib (INCB018424) is a JAK1/2 inhibitor (IC50=3.3/2.8 nM) that is potent and selective.

• Formula: C₁₇H₁₈N₆
• Purity: 100% - 99.99%
• Color and Shape: Solid
• Molecular weight: 306.36

Ruxolitinib (free base)

CAS: 941678-49-5

Ruxolitinib-d4

CAS: 941678-49-5

• Formula: C₁₇H₁₄N₆D₄
• Molecular weight: 310.40

3-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-(β-R)-1H-pyrazole-1-propanenitrile

CAS: 941678-49-5

• Purity: 95.0%
• Color and Shape: Solid
• Molecular weight: 306.373

(R)-Ruxolitinib (>90%)

CAS: 941678-49-5

Applications Ruxolitinib is a selective Janus tyrosine kinase (JAK1 and JAK2) inhibitor used in the …

• Formula: C₁₇H₁₈N₆
• Purity: >90%
• Color and Shape: White To Beige
• Molecular weight: 306.36

Ruxolitinib

CAS: 941678-49-5

Ruxolitinib is a janus tyrosine kinase inhibitor active specifically on sub-types JAK1 and JAK2 with …

• Formula: C₁₇H₁₈N₆
• Purity: Min. 95%
• Color and Shape: White Powder
• Molecular weight: 306.37 g/mol