CAS 94168-98-6

Rifametane

Description:

Rifametane, identified by its CAS number 94168-98-6, is a chemical compound that belongs to the class of rifamycin antibiotics. It is primarily used in the treatment of bacterial infections, particularly those caused by Mycobacterium tuberculosis. The compound exhibits a complex structure characterized by a naphthalenic core and various functional groups that contribute to its antibacterial activity. Rifametane works by inhibiting bacterial RNA synthesis, thereby preventing the growth and replication of bacteria. Its pharmacokinetic properties include good oral bioavailability and a relatively long half-life, which allows for convenient dosing regimens. Additionally, like other rifamycins, rifametane may interact with various cytochrome P450 enzymes, potentially affecting the metabolism of co-administered drugs. Side effects can include gastrointestinal disturbances and potential liver toxicity, necessitating monitoring during treatment. Overall, rifametane represents an important therapeutic option in the management of resistant bacterial infections, particularly in the context of tuberculosis treatment.

Formula: C₄₄H₆₀N₄O₁₂

InChI: InChI=1/C44H60N4O12/c1-13-48(14-2)27(9)47-45-20-29-34-39(54)32-31(38(29)53)33-41(26(8)37(32)52)60-44(11,42(33)55)58-19-18-30(57-12)23(5)40(59-28(10)49)25(7)36(51)24(6)35(50)21(3)16-15-17-22(4)43(56)46-34/h15-21,23-25,30,35-36,40,45,50-52,54H,13-14H2,1-12H3,(H,46,56)/b16-15+,19-18+,22-17+,29-20u,47-27-

Synonyms:

• (24E)-8-({(2Z)-2-[1-(diethylamino)ethylidene]hydrazinyl}methylidene)-5,6,17,19-tetrahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,9,11-trioxo-1,2,8,9-tetrahydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate
• (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22S,23S,24E)-1,2-Dihydro-5,6,9,17,19,21-hexahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-2,7-(epoxypentadeca(1,11,13)trienimino)naphtho(2,1-b)furan-8-carboxyaldehyde, 8-azine with N,N-diethylacetamide, 21-acetate
• Rifametane [USAN:INN]
• Rifametano [INN-Spanish]
• Spa-S 565
• Rifametanum
• Rifametanum [INN-Latin]
• Rifametano
• SPA S565
• UNII-1PUG6262HX
• Rifamycin, 3-(((1-(diethylamino)ethylidene)hydrazono)methyl)-
• Rifametane
• 3-[(1-diethylaminoethylidene)azinomethyl]rifamycin SV

Rifametane

CAS: 94168-98-6

Rifametane is a new semi-synthetic rifamycin, an antibiotic produced naturally by the bacterium Amycolatopsis rifamycinica.

Formula: C₄₄H₆₀N₄O₁₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 836.98

Ref: TM-T26083