CAS 941685-37-6

Incb 18424

Description:

Incb 18424, with the CAS number 941685-37-6, is a chemical compound that has garnered attention in the field of medicinal chemistry, particularly for its potential therapeutic applications. It is classified as a small molecule and is known to exhibit properties that may influence biological pathways, making it a candidate for drug development. The compound's structure typically includes specific functional groups that contribute to its reactivity and interaction with biological targets. While detailed pharmacological data may vary, compounds like Incb 18424 are often evaluated for their efficacy, safety, and mechanism of action in preclinical and clinical studies. Additionally, its solubility, stability, and bioavailability are critical factors that determine its suitability for therapeutic use. As research progresses, further insights into its characteristics, including its pharmacokinetics and potential side effects, will be essential for understanding its role in medical applications.

Formula: C₁₇H₁₇N₆

InChI: InChI=1S/C17H18N6/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16/h6,8-12,15H,1-5H2,(H,19,20,21)/t15-/m0/s1

InChI key: InChIKey=HFNKQEVNSGCOJV-HNNXBMFYSA-N

SMILES: [C@@H](CC#N)(N1C=C(C2=C3C(=NC=N2)NC=C3)C=N1)C4CCCC4

Synonyms:

• S-Ruxolitinib (INCB018424)
• CS-1401
• S-Ruxolitinib
• Ruxolitinib Impurity A
• Ruxolitinib Impurity 1（(S)-Ruxolitinib）
• (S)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile
• RUXOLITINIB S ENANTIOMER;INCB18424
• (3S)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyriMidin-4-yl)-1H-pyrazol-1-yl]propanenitrile
• (3S)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile (ent-Ruxolitinib)
• Ruxolitinib (S enantioMer)
• 1H-Pyrazole-1-propanenitrile, β-cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-, (βS)-

1H-Pyrazole-1-propanenitrile, β-cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-, (βS)-

CAS: 941685-37-6

Formula: C₁₇H₁₈N₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 306.3650

Ref: IN-DA000BIK

Ruxolitinib (S enantiomer)

CAS: 941685-37-6

Ruxolitinib (S enantiomer)

Purity: ≥98%

Molecular weight: 306.36g/mol

Ref: 54-BUP14440

(S)-Ruxolitinib

CAS: 941685-37-6

Formula: C₁₇H₁₈N₆

Color and Shape: White To Off-White Solid

Molecular weight: 306.37

Ref: 4Z-R-093003

Ruxolitinib (S enantiomer)

CAS: 941685-37-6

Ruxolitinib S enantiomer (INCB18424) is the S-enantiomer of Ruxolitinib. Ruxolitinib is the first potent, selective JAK1/2 inhibitor.

Formula: C₁₇H₁₈N₆

Purity: 99.37% - 99.79%

Color and Shape: Solid

Molecular weight: 306.36

Ref: TM-T6156

(S)-Ruxolitinib

Controlled Product

CAS: 941685-37-6

Applications (3S)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile is a newly developed JAK2 inhibitor therapy aimed to improve MPN-associated splenomegaly and systemic symptoms. The opposite enantiomer of Ruxolitinib (R702000).
References Koppikar, P., et al.: Nature., 489, 155 (2012); Ratcliffe, A.J., et al.: Drug. Discover. Series., 19, 218 (2012);

Formula: C₁₇H₁₈N₆

Color and Shape: Neat

Molecular weight: 306.36

Ref: TR-C988940

S-Ruxolitinib (INCB018424)

CAS: 941685-37-6

Ruxolitinib is a janus tyrosine kinase inhibitor active specifically on sub-types JAK1 and JAK2 with IC50 values in the nanomolar range. JAK1 and JAK2 are kinases involved in the regulation of hematopoiesis. Clinically applied to the treatment of intermediate and high-risk myelofibrosis, ruxolitinib is usually well tolerated by patients.

Formula: C₁₇H₁₈N₆

Purity: Min. 95%

Molecular weight: 306.37 g/mol

Ref: 3D-RMB68537

(S)-Ruxolitinib

CAS: 941685-37-6

Formula: C₁₇H₁₈N₆

Molecular weight: 306.4

Ref: ST-EA-CP-R53030