CAS 942206-85-1

Gsk 10116790A

Description:

GSK 10116790A, with the CAS number 942206-85-1, is a chemical compound that has been investigated primarily for its potential therapeutic applications, particularly in the field of neuroscience. It is classified as a small molecule and is known to act as a selective modulator of certain receptors in the central nervous system. The compound exhibits properties that may influence neurotransmitter systems, making it a candidate for research into treatments for various neurological disorders. Its molecular structure includes specific functional groups that contribute to its biological activity and pharmacokinetic profile. While detailed information on its solubility, stability, and specific interactions may vary, ongoing studies aim to elucidate its mechanism of action and therapeutic potential. As with many investigational compounds, safety and efficacy assessments are critical components of its development process. Overall, GSK 10116790A represents a promising area of research within medicinal chemistry and pharmacology.

Formula: C₂₈H₃₂Cl₂N₄O₆S₂

InChI: InChI=1S/C28H32Cl2N4O6S2/c1-17(2)13-21(31-26(36)24-14-18-5-3-4-6-23(18)41-24)27(37)33-9-11-34(12-10-33)28(38)22(16-35)32-42(39,40)25-8-7-19(29)15-20(25)30/h3-8,14-15,17,21-22,32,35H,9-13,16H2,1-2H3,(H,31,36)/t21-,22-/m0/s1

InChI key: InChIKey=IVYQPSHHYIAUFO-VXKWHMMOSA-N

SMILES: C(N[C@H](C(=O)N1CCN(C([C@@H](NS(=O)(=O)C2=C(Cl)C=C(Cl)C=C2)CO)=O)CC1)CC(C)C)(=O)C3=CC=4C(S3)=CC=CC4

Synonyms:

• GSK1016790A
• GSK1016790A;GSK-1016790A;GSK 1016790A
• CS-2774
• (N-((1S)-1-{[4-((2S)-2-{[(2,4-Dichlorophenyl)sulfonyl]amino}-3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide
• GSK-1016790A;GSK 1016790A
• N-((S)-1-(4-(((2,4-dichlorophenyl)sulfonyl)-L-seryl)piperazin-1-yl)-4-methyl-1-oxopentan-2-yl)benzo[b]thiophene-2-carboxamide
• GSK101
• N-((S)-1-(4-((S)-2-(2,4-dichlorophenylsulfonaMido)-3-hydroxypropanoyl)piperazin-1-yl)-4-Methyl-1-oxopentan-2-yl)benzo[b]thiophene-2-carboxaMide
• Benzo[b]thiophene-2-carboxamide, N-[(1S)-1-[[4-[(2S)-2-[[(2,4-dichlorophenyl)sulfonyl]amino]-3-hydroxy-1-oxopropyl]-1-piperazinyl]carbonyl]-3-methylbutyl]-

N-((S)-1-(4-((S)-2-(2,4-dichlorophenylsulfonamido)-3-hydroxypropanoyl)piperazin-1-yl)-4-methyl-1-oxopentan-2-yl)benzo[b]thiophene-2-carboxamide

CAS: 942206-85-1

Formula: C₂₈H₃₂Cl₂N₄O₆S₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 655.6129

Ref: IN-DA00GUB4

GSK1016790A

CAS: 942206-85-1

GSK1016790A

Purity: ≥95%

Molecular weight: 655.61g/mol

Ref: 54-BUP12454

GSK1016790A

CAS: 942206-85-1

Formula: C₂₈H₃₂Cl₂N₄O₆S₂

Purity: ≥ 97%

Color and Shape: White solid

Molecular weight: 655.61

Ref: 7W-GL8092

GSK1016790A

CAS: 942206-85-1

GSK1016790A (GSK101) (GSK101) is a novel, potent activator of TRPV4 (transient receptor potential vanilloid 4) with EC50 of 34 nM in choroid plexus epithelial

Formula: C₂₈H₃₂Cl₂N₄O₆S₂

Purity: 97.37% - 99.38%

Color and Shape: Solid

Molecular weight: 655.61

Ref: TM-T6848

GSK1016790A

CAS: 942206-85-1

Purity: 98%

Molecular weight: 655.610

Ref: 10-F863774

GSK 1016790A

Controlled Product

CAS: 942206-85-1

Applications GSK 1016790A is a transient receptor potential vanilloid 4 (TRPV4) agonist.
References Egbuniwe, O., et. al.: J. Dent. Res., 93, 911 (2014); Yamawaki, H., et. al.: Am. J. Phys., 307, g33 (2014)

Formula: C₂₈H₃₂Cl₂N₄O₆S₂

Color and Shape: Neat

Molecular weight: 655.61

Ref: TR-G797440

GSK1016790A

CAS: 942206-85-1

GSK1016790A is a potent and selective small molecule inhibitor of TRPV4, a member of the transient receptor potential (TRP) channel family. It is currently being investigated for pharmacological effects in vitro and in vivo. GSK1016790A has been shown to inhibit the activity of TRPV4 channels in neuronal cells, leading to an increase in intracellular calcium levels and subsequent neuronal death. This agent also blocks the angiotensin system, which may have physiological implications including regulation of blood pressure. GSK1016790A binds to calcium binding sites on the cytosolic side of TRPV4 channels where it acts as a competitive antagonist. The compound is stable over a wide pH range and does not show any significant effect on cellular viability at concentrations up to 100 µM.

Formula: C₂₈H₃₂Cl₂N₄O₆S₂

Purity: Min. 95%

Molecular weight: 655.61 g/mol

Ref: 3D-SMB20685