CAS 943540-75-8

6-[Difluoro[6-(1-methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]methyl]quinoline

Description:

6-[Difluoro[6-(1-methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]methyl]quinoline, with the CAS number 943540-75-8, is a synthetic organic compound characterized by its complex molecular structure, which includes a quinoline core and multiple heterocyclic components. This compound features difluoromethyl and pyrazole substituents, contributing to its potential biological activity. The presence of the triazole and pyridazine rings suggests that it may exhibit interesting pharmacological properties, possibly acting as a ligand or inhibitor in various biochemical pathways. Its unique arrangement of functional groups may influence its solubility, stability, and reactivity, making it a candidate for research in medicinal chemistry. Additionally, the compound's structural complexity may allow for interactions with specific biological targets, warranting further investigation into its therapeutic potential. As with many synthetic compounds, safety and handling precautions should be observed, and its properties should be characterized through appropriate analytical techniques.

Formula: C₁₉H₁₃F₂N₇

InChI: InChI=1S/C19H13F2N7/c1-27-11-13(10-23-27)16-6-7-17-24-25-18(28(17)26-16)19(20,21)14-4-5-15-12(9-14)3-2-8-22-15/h2-11H,1H3

InChI key: InChIKey=JRWCBEOAFGHNNU-UHFFFAOYSA-N

SMILES: C(F)(F)(C=1N2C(=NN1)C=CC(=N2)C3=CN(C)N=C3)C4=CC5=C(C=C4)N=CC=C5

Synonyms:

• 6-[Difluoro[6-(1-methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]methyl]quinoline
• J&J Ex-61
• Jnj 38877605
• Quinoline,6-[difluoro[6-(1-methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]methyl]-

6-[Difluoro[6-(1-methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]methyl]quinoline

CAS: 943540-75-8

Formula: C₁₉H₁₃F₂N₇

Purity: %

Color and Shape: Solid

Molecular weight: 377.3502

Ref: IN-DA01DNTL

JNJ-38877605

CAS: 943540-75-8

JNJ-38877605

Purity: ≥95%

Molecular weight: 377.35g/mol

Ref: 54-BUP14265

JNJ-38877605

CAS: 943540-75-8

JNJ-38877605 is an ATP-competitive c-Met inhibitor (IC50: 4 nM), 600-fold selective for c-Met than 200 other tyrosine and serine-threonine kinases.

Formula: C₁₉H₁₃F₂N₇

Purity: 97.15% - 98.61%

Color and Shape: Solid

Molecular weight: 377.35

Ref: TM-T6095

JNJ-38877605

CAS: 943540-75-8

Ref: 7W-GW6703

JNJ 38877605

CAS: 943540-75-8

Potent inhibitor of c-Met catalytic activity. Selective over other tyrosine and serine-threonine kinases (600-fold selectivity). Ability to block constitutive or HGF-stimulated phosphorylation of c-Met demonstrated in vitro. JNJ 38877605 reduces radiation-induced invasion, apoptosis and proliferation of cancer cells in vitro.

Formula: C₁₉H₁₃F₂N₇

Purity: Min. 95%

Color and Shape: Solid

Molecular weight: 377.12005

Ref: 3D-BJ165317