CAS 94367-21-2

Suc-Leu-Leu-Val-Tyr-AMC

Description:

Suc-Leu-Leu-Val-Tyr-AMC, also known as a peptide substrate, is a synthetic compound that consists of a sequence of amino acids: succinylated leucine, leucine, valine, tyrosine, and 7-amido-4-methylcoumarin (AMC). This compound is primarily used in biochemical assays to study proteolytic enzymes, particularly those that cleave peptide bonds. The succinyl group enhances the solubility and stability of the peptide, while the AMC moiety serves as a fluorescent reporter, allowing for the detection of enzymatic activity through fluorescence measurements. The characteristics of this substance include its ability to undergo hydrolysis by specific proteases, resulting in the release of AMC, which can be quantitatively measured. This property makes it valuable in research applications, particularly in the fields of enzymology and drug discovery. Additionally, the structure of Suc-Leu-Leu-Val-Tyr-AMC contributes to its specificity for certain enzymes, making it a useful tool for studying enzyme kinetics and inhibition.

Formula: C₄₀H₅₃N₅O₁₀

InChI: InChI=1/C40H53N5O10/c1-21(2)16-29(42-33(47)14-15-34(48)49)38(52)43-30(17-22(3)4)39(53)45-36(23(5)6)40(54)44-31(19-25-8-11-27(46)12-9-25)37(51)41-26-10-13-28-24(7)18-35(50)55-32(28)20-26/h8-13,18,20-23,29-31,36,46H,14-17,19H2,1-7H3,(H,41,51)(H,42,47)(H,43,52)(H,44,54)(H,45,53)(H,48,49)/t29?,30?,31-,36-/m0/s1

SMILES: CC(C)CC(C(=NC(CC(C)C)C(=N[C@@H](C(C)C)C(=N[C@@H](Cc1ccc(cc1)O)C(=Nc1ccc2c(C)cc(=O)oc2c1)O)O)O)O)N=C(CCC(=O)O)O

Synonyms:

• N-succinyl-leu-leu-val-tyr 7-amido-4-*methylcouma
• Succinyl-leucyl-leucyl-valyl-tyrosyl-methylcoumarinamide
• Llvy-mca
• N-Succinyl-leu-leu-val-tyr-7-amido-4-methylcoumarin
• Sllvt-mca
• Suc-leu-leu-val-tyr-7-amino-4-methylcoumarin
• Suc-leu-leu-val-tyr-mca
• Suc-llvy-mca
• L-Tyrosinamide, N-(3-carboxy-1-oxopropyl)-L-leucyl-L-leucyl-L-valyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-
• N-(3-carboxypropanoyl)leucylleucyl-L-valyl-N-(4-methyl-2-oxo-2H-chromen-7-yl)-L-tyrosinamide

Suc-Leu-Leu-Val-Tyr-AMC

CAS: 94367-21-2

The fluorogenic substrate Suc-LLVY-AMC is used for measuring the chymotrypsin-like activity of the 20S proteasome, in combination with e.g. Bz-VGR-AMC (for assaying its trypsin-like activity) and Z-LLE-AMC (for determining its PGPH activity). Suc-LLVY-AMC is also cleaved by a chymotrypsin-like enzyme from sperm extract of the ascidian Halocynthia roretzi, a strong inhibitor of fertilization. The substrate has also been used to analyze the chymotrypsin-like activity of trypsins as well as chymase from rat mast cells. Furthermore, Suc-LLVY-AMC is a substrate for carboxypeptidase Y, proteinase yscE (kexin), ingensin, as well as for porcine calpain isozymes I and II and for papain.

Formula: C₄₀H₅₃N₅O₁₀

Purity: > 98%

Color and Shape: White

Molecular weight: 763.89

Ref: 01-4011369

Suc-Leu-Leu-Val-Tyr-AMC

CAS: 94367-21-2

Formula: C₄₀H₅₃N₅O₁₀

Purity: 95%

Color and Shape: Solid

Molecular weight: 763.8763

Ref: IN-DA01E5Y8

Suc-Leu-Leu-Val-Tyr-AMC

CAS: 94367-21-2

Suc-Leu-Leu-Val-Tyr-AMC is a fluorescent substrate for the 20S proteasome, other chymotrypsin-like proteases.

Formula: C₄₀H₅₃N₅O₁₀

Purity: 98%

Color and Shape: Solid

Molecular weight: 763.88

Ref: TM-TP1308

N-Succinyl-Leu-Leu-Val-Tyr-7-Amido-4-Methylcoumarin

CAS: 94367-21-2

Formula: C₄₀H₅₃N₅O₁₀

Purity: ≥ 95.0%

Color and Shape: White to off-white powder

Molecular weight: 763.89

Ref: 7W-GL1880

Suc-Leu-Leu-Val-Tyr-AMC

CAS: 94367-21-2

Suc-Leu-Leu-Val-Tyr-AMC is a peptide that is an activator of ion channels. It can be used to study the effects of ion channel activation on various cells and tissues. Suc-Leu-Leu-Val-Tyr-AMC has also been shown to inhibit ligand binding to some receptors, such as the acetylcholine receptor. This peptide can also be used as a research tool for pharmacology, protein interactions, and antibody production.

Formula: C₄₀H₅₃N₅O₁₀

Purity: Min. 95%

Molecular weight: 763.88 g/mol

Ref: 3D-MLL-3120-V

Suc-Leu-Leu-Val-Tyr-AMC

CAS: 94367-21-2

Suc-Leu-Leu-Val-Tyr-AMC is a cyclin D2 inhibitor that binds to the proteasome and inhibits its function. It has been shown to be useful for the treatment of cancerous tissues as it inhibits the production of prostaglandin J2, which is involved in the progression of cancer cells. Suc-Leu-Leu-Val-Tyr-AMC has also been shown to have antioxidant properties and can inhibit oxidative injury. This drug may be used to prevent or treat various diseases such as Parkinson's disease, Alzheimer's disease, Huntington's disease, diabetes mellitus type II, amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), and septic shock.

Formula: C₄₀H₅₃N₅O₁₀

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 763.88 g/mol

Ref: 3D-FS110535