CAS 944118-01-8

Peficitinib

Description:

Peficitinib is a small molecule drug that functions as a selective inhibitor of Janus kinase (JAK) enzymes, particularly JAK1, which play a crucial role in the signaling pathways of various cytokines and growth factors. This compound is primarily utilized in the treatment of autoimmune diseases, such as rheumatoid arthritis, by modulating the immune response. Peficitinib exhibits a favorable pharmacokinetic profile, allowing for oral administration, and is characterized by its ability to reduce inflammation and improve symptoms associated with chronic inflammatory conditions. The chemical structure of peficitinib includes a pyrimidine ring, contributing to its biological activity and selectivity. Its mechanism of action involves the inhibition of JAK-mediated signaling, which subsequently leads to decreased production of pro-inflammatory cytokines. As with many JAK inhibitors, potential side effects may include increased risk of infections and changes in blood cell counts, necessitating careful monitoring during treatment. Overall, peficitinib represents a significant advancement in targeted therapies for inflammatory diseases.

Formula: C₁₈H₂₂N₄O₂

InChI: InChI=1/C18H22N4O2/c19-16(23)13-8-21-17-12(1-2-20-17)15(13)22-14-10-3-9-4-11(14)7-18(24,5-9)6-10/h1-2,8-11,14,24H,3-7H2,(H2,19,23)(H2,20,21,22)/t9?,10-,11+,14-,18?

InChI key: InChIKey=DREIJXJRTLTGJC-YFOKXDAVNA-N

SMILES: N([C@H]1[C@@]2(CC3(O)C[C@]1(CC(C2)C3)[H])[H])C4=C5C(=NC=C4C(N)=O)NC=C5

Synonyms:

• Peficitinib
• 4-[(anti-5-Hydroxyadamantan-2-yl)amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide
• stereoisomer of 4-[(5-Hydroxytricyclo[3.3.1.13,7]dec-2-yl)amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide
• 4-[(trans-5-Hydroxyadamantan-2-yl)amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide
• 1H-Pyrrolo[2,3-b]pyridine-5-carboxamide, 4-[(5-hydroxytricyclo[3.3.1.13,7]dec-2-yl)amino]-, stereoisomer
• JNJ-54781532
• ASP015K;JNJ-54781532
• 4-[[(1R,3S)-5-hydroxy-2-adamantyl]amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide
• 4-(((1R,2s,3S,5r)-5-hydroxyadamantan-2-yl)amino)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide
• Carotegrast methyl
• ASP015K;JNJ-54781532;ASP-015K;ASP 015K;JNJ54781532;JNJ 54781532
• CS-2584
• Peficitinb (ASP015K, JNJ-54781532)

Peficitinib

CAS: 944118-01-8

Formula: C₁₈H₂₂N₄O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 326.3929

Ref: IN-DA00II55

Peficitinib

CAS: 944118-01-8

Peficitinib

Purity: ≥98%

Molecular weight: 326.39g/mol

Ref: 54-BUP09929

Peficitinib

CAS: 944118-01-8

Formula: C₁₈H₂₂N₄O₂

Molecular weight: 326.40

Ref: 4Z-P-474001

Peficitinib

CAS: 944118-01-8

Peficitinib (ASP015K) (ASP015K, JNJ-54781532) is an orally bioavailable JAK inhibitor. Phase 3.

Formula: C₁₈H₂₂N₄O₂

Purity: 98.67% - 99.4%

Color and Shape: Solid

Molecular weight: 326.39

Ref: TM-T6933