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CAS 944283-09-4

:

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-leucine 2-carboxy-2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl ester

Description:
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-leucine 2-carboxy-2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl ester, commonly referred to as Fmoc-L-leucine derivative, is a synthetic amino acid derivative primarily used in peptide synthesis and research. This compound features a fluorenylmethoxycarbonyl (Fmoc) protecting group, which is widely utilized in solid-phase peptide synthesis due to its stability under basic conditions and ease of removal under acidic conditions. The structure includes a leucine residue, an essential branched-chain amino acid, contributing to the hydrophobic characteristics of peptides. The presence of the dimethylethoxycarbonyl group enhances the compound's solubility and stability. This substance is typically a white to off-white solid and is soluble in organic solvents like dimethyl sulfoxide (DMSO) and dichloromethane. Its molecular structure allows for specific interactions in biological systems, making it valuable in the development of peptide-based therapeutics and research applications. Proper handling and storage are essential to maintain its integrity and reactivity during synthesis processes.
Formula:C29H36N2O8
InChI:InChI=1S/C29H36N2O8/c1-17(2)14-23(26(34)37-16-24(25(32)33)31-28(36)39-29(3,4)5)30-27(35)38-15-22-20-12-8-6-10-18(20)19-11-7-9-13-21(19)22/h6-13,17,22-24H,14-16H2,1-5H3,(H,30,35)(H,31,36)(H,32,33)/t23-,24-/m0/s1
InChI key:InChIKey=ZBFDFHFWCCHHIV-ZEQRLZLVSA-N
SMILES:C(OC(N[C@H](C(OC[C@H](NC(OC(C)(C)C)=O)C(O)=O)=O)CC(C)C)=O)C1C=2C(C=3C1=CC=CC3)=CC=CC2
Synonyms:
  • L-Leucine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, 2-carboxy-2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl ester
  • N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-leucine 2-carboxy-2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl ester
  • O-((((9H-fluoren-9-yl)methoxy)carbonyl)-L-leucyl)-N-(tert-butoxycarbonyl)-L-serine
  • (2S)-2-{[(tert-butoxy)carbonyl]amino}-3-{[(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-methylpentanoyl]oxy}propanoic acid
  • (Tert-Butoxy)Carbonyl Ser((9H-Fluoren-9-yl)MethOxy]Carbonyl Leu)-OH
  • (2S)-3-[(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methylpentanoyl]oxy-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid
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