CAS 944396-07-0

Buparlisib

Description:

Buparlisib, also known by its chemical name, is a selective inhibitor of the phosphoinositide 3-kinase (PI3K) pathway, which plays a crucial role in cell growth, proliferation, and survival. It is primarily investigated for its potential therapeutic applications in oncology, particularly for treating various types of cancer, including breast cancer and other solid tumors. Buparlisib exhibits a unique mechanism of action by targeting the PI3K pathway, which is often dysregulated in cancer cells. The substance is typically administered orally and has been studied in combination with other therapies to enhance its efficacy. Its chemical structure includes a pyrimidine ring, contributing to its biological activity. As with many investigational drugs, the pharmacokinetics, safety profile, and potential side effects are subjects of ongoing research. Overall, Buparlisib represents a promising avenue in targeted cancer therapy, aiming to improve patient outcomes by specifically inhibiting pathways that contribute to tumor growth and resistance to treatment.

Formula: C₁₈H₂₁F₃N₆O₂

InChI: InChI=1S/C18H21F3N6O2/c19-18(20,21)13-9-15(22)23-11-12(13)14-10-16(26-1-5-28-6-2-26)25-17(24-14)27-3-7-29-8-4-27/h9-11H,1-8H2,(H2,22,23)

InChI key: InChIKey=CWHUFRVAEUJCEF-UHFFFAOYSA-N

SMILES: C(F)(F)(F)C=1C(C=2C=C(N=C(N2)N3CCOCC3)N4CCOCC4)=CN=C(N)C1

Synonyms:

• 2-Pyridinamine, 5-(2,6-di-4-morpholinyl-4-pyrimidinyl)-4-(trifluoromethyl)-
• 5-(2,6-Dimorpholinopyrimidin-4-yl)-4-(trifluoromethyl)pyridine-2-amine
• Bkm 120
• Bkm 120Nx
• Bkm120
• Buparlisib
• Nvp-Bkm 120
• Nvp-Bkm120
• 5-(2,6-diMorpholinopyriMidin-4-yl)-4-(trifluoroMethyl)pyridin-2-aMine
• 5-(2,6-Di-4-morpholinyl-4-pyrimidinyl)-4-(trifluoromethyl)-2-pyridinamine

5-(2,6-Di-4-morpholinyl-4-pyrimidinyl)-4-(trifluoromethyl)-2-pyridinamine

CAS: 944396-07-0

Formula: C₁₈H₂₁F₃N₆O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 410.3935

Ref: IN-DA0036OW

Buparlisib

CAS: 944396-07-0

Buparlisib

Purity: ≥95%

Molecular weight: 410.39g/mol

Ref: 54-BUP13177

Buparlisib

CAS: 944396-07-0

Buparlisib (BKM120) is an orally bioavailable specific oral inhibitor of the pan-class I PI3K (IC50s: 52/166/116/nM for p110α, p110β, and p110δ).

Formula: C₁₈H₂₁F₃N₆O₂

Purity: 95.32% - 98.45%

Color and Shape: Solid

Molecular weight: 410.39

Ref: TM-T1827

NVP-BKM 120

Controlled Product

CAS: 944396-07-0

Stability Hygroscopic
Applications NVP-BKM 120 is a novel anti-tumor active compound that is selective in that it inhibits specifically PI3 kinase activating cell death in glioma cells. Glioma cells being those that proliferate from tumors in the brain or the spine.
References Koul, D. et al.: Clin. Cancer Res., 18, 184 (2012);

Formula: C₁₈H₂₁F₃N₆O₂

Color and Shape: White To Off-White

Molecular weight: 410.39

Ref: TR-N925760

BKM 120

CAS: 944396-07-0

Inhibitor of pan-class I PI3K family of lipid kinases; antineoplastic

Formula: C₁₈H₂₁O₂N₆F₃

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 410.39 g/mol

Ref: 3D-FD64903

NVP-BKM 120-d16 Hydrochloride

Controlled Product

CAS: 1312445-63-8, 944396-07-0

Formula: C₁₈H₆D₁₆ClF₃N₆O₂

Color and Shape: Neat

Molecular weight: 462.95

Ref: TR-N925763

NVP-BKM 120-13C3 Hydrochloride

Controlled Product

CAS: 1312445-63-8, 944396-07-0

Formula: C₁₅C₃H₂₂ClF₃N₆O₂

Color and Shape: Neat

Molecular weight: 449.83

Ref: TR-N925762