CAS 94470-67-4

Cromakalim

Description:

Cromakalim is a chemical compound classified as a potassium channel opener, primarily used in pharmacological research and potential therapeutic applications. It is known for its ability to induce vasodilation by facilitating the efflux of potassium ions from smooth muscle cells, leading to relaxation of vascular tissues. Cromakalim is often studied for its effects on cardiovascular health, particularly in relation to hypertension and ischemic conditions. The compound has a relatively low solubility in water, which can influence its bioavailability and pharmacokinetics. Its mechanism of action involves the activation of ATP-sensitive potassium channels, which play a crucial role in regulating cellular excitability and vascular tone. Additionally, Cromakalim has been investigated for its neuroprotective properties and potential applications in treating conditions such as stroke. However, its clinical use is limited, and it is primarily utilized in research settings to better understand potassium channel modulation and its implications in various physiological and pathological processes.

Formula: C₁₆H₁₈N₂O₃

InChI: InChI=1/C16H18N2O3/c1-16(2)15(20)14(18-7-3-4-13(18)19)11-8-10(9-17)5-6-12(11)21-16/h5-6,8,14-15,20H,3-4,7H2,1-2H3

InChI key: InChIKey=TVZCRIROJQEVOT-PVRQQBJHNA-N

SMILES: O[C@@H]1[C@H](C=2C(OC1(C)C)=CC=C(C#N)C2)N3C(=O)CCC3

Synonyms:

• (+-)-trans-3-Hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-6-chromancarbonitrile
• (3R,4S)-3-hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)-3,4-dihydro-2H-chromene-6-carbonitrile
• (3S,4R)-3-hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)-3,4-dihydro-2H-chromene-6-carbonitrile
• 2H-1-Benzopyran-6-carbonitrile, 3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-, (3R,4S)-rel-
• 2H-1-Benzopyran-6-carbonitrile, 3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-, trans-(+-)-
• 3-hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)-3,4-dihydro-2H-chromene-6-carbonitrile
• Brl 34915
• Cromakalim [INN:BAN]
• Cromakalime
• Cromakalime [French]
• Cromakalimum
• Cromakalimum [Latin]
• Unii-0G4X367Wa3
• rel-(3R,4S)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile
• Cromakalim
• Cromakalim
• (-trans-6-Cyano-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-3,4-dihydro-2H-benzo[b]pyran-3-ol
• AKOS 91890
• (+/-)-TRANS-6-CYANO-3,4-DIHYDRO-2,2-DIMETHYL-4-(2-OXOPYRROLIDIN-1-YL)-2H-1-BENZOPYRAN-3-OL
• rac-(3α*,4β*)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxopyrrolidine-1-yl)-2H-1-benzopyran-6-carbonitrile
• [+/-]-TRANS-6-CYANO-3,4-DIHYDRO-2,2-DIMETHYL-4-[2-OXOPYRROLIDIN-1-YL]-2H-1-BENZOPYRAN-3-OL
• Cromakalim=([+/-]-trans-6-Cyano-3,4-dihydro-2,2-
• rac-(3α*,4β*)-3-Hydroxy-2,2-dimethyl-4-(2-oxopyrrolidine-1-yl)chroman-6-carbonitrile
• (3R,4S)-rel-3,4-Dihydro-3-hydroxy-2,2-diMethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile
• TRANS-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-4-(2-OXO-1-PYRROLIDINYL)-2H-1-BENZOPYRAN-6-CARBONITRILE

Cromakalim

CAS: 94470-67-4

Cromakalim

Purity: ≥98%

Molecular weight: 286.33g/mol

Ref: 54-BUP21867

Cromakalim

CAS: 94470-67-4

Formula: C₁₆H₁₈N₂O₃

Molecular weight: 286.33

Ref: 7W-GL0832

Cromakalim

CAS: 94470-67-4

Cromakalim (BRL 34915) is an ATP-dependent K(+) channel opener, a smooth muscle relaxant with antiepileptic activity.

Formula: C₁₆H₁₈N₂O₃

Purity: 99.39%

Color and Shape: Solid

Molecular weight: 286.33

Ref: TM-T21478

(+/-)-Cromakalim

Controlled Product

CAS: 94470-67-4

Applications Causes vasodilation by activation of potassim channels.
References Lijnen, P., et al.: Eur. J. Clin. Pharmacol., 37, 609(1989), Spinelli, W., et al.: Eur. J. Pharmacol., 179, 243 (1990)

Formula: C₁₆H₁₈N₂O₃

Color and Shape: Neat

Molecular weight: 286.33

Ref: TR-C795000