CAS 94497-51-5

Tamibarotene

Description:

Tamibarotene is a synthetic retinoid, primarily known for its application in the treatment of acute promyelocytic leukemia (APL). It functions as a selective agonist of retinoic acid receptors, particularly RARα, which plays a crucial role in regulating gene expression involved in cell differentiation and proliferation. Tamibarotene exhibits a high affinity for these receptors, promoting the maturation of promyelocytes into mature granulocytes, thereby aiding in the therapeutic process for APL. The compound is characterized by its ability to modulate various biological pathways, including apoptosis and cell cycle regulation. In terms of physical properties, Tamibarotene is typically presented as a white to off-white crystalline powder, with moderate solubility in organic solvents and limited solubility in water. Its pharmacokinetics involve oral administration, with a favorable absorption profile. As with many retinoids, potential side effects may include skin-related reactions and teratogenic effects, necessitating careful monitoring during treatment. Overall, Tamibarotene represents a significant advancement in targeted cancer therapies, particularly for hematological malignancies.

Formula: C₂₂H₂₅NO₃

InChI: InChI=1S/C22H25NO3/c1-21(2)11-12-22(3,4)18-13-16(9-10-17(18)21)23-19(24)14-5-7-15(8-6-14)20(25)26/h5-10,13H,11-12H2,1-4H3,(H,23,24)(H,25,26)

InChI key: InChIKey=MUTNCGKQJGXKEM-UHFFFAOYSA-N

SMILES: CC1(C)C=2C(=CC(NC(=O)C3=CC=C(C(O)=O)C=C3)=CC2)C(C)(C)CC1

Synonyms:

• 4-[[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)amino]carbonyl]benzoic acid
• AM80
• Retinoid AM 80
• 4-[(5,5,8,8-Tetramethyl-6,7-dihydronaphthalen-2-yl)carbamoyl]benzoic acid
• 4-[[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)amino]carbonyl]benzoic Acid
• Amnolake
• Tamibarotene
• 4-[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbamoyl]benzoic acid
• Am 80 (pharmaceutical)
• NSC 608000
• Am 80
• Am 80 (pharmaceutical)

Tamibarotene

CAS: 94497-51-5

A retinoic acid receptor (RAR) agonist

Formula: C₂₂H₂₅NO₃

Molecular weight: 351.44

Ref: 02-J64028

4-[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbamoyl]benzoic acid

CAS: 94497-51-5

Formula: C₂₂H₂₅NO₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 351.4388

Ref: IN-DA0038IQ

Tamibarotene

CAS: 94497-51-5

Tamibarotene

Purity: 98%

Molecular weight: 351.44g/mol

Ref: 54-OR1027732

Tamibarotene

CAS: 94497-51-5

Formula: C₂₂H₂₅NO₃

Molecular weight: 351.44

Ref: 7W-GP8128

Tamibarotene

CAS: 94497-51-5

Tamibarotene

Purity: ≥95%

Molecular weight: 351.44g/mol

Ref: 54-BUP15029

Tamibarotene

CAS: 94497-51-5

Tamibarotene (Amnolake) is an orally active, synthetic retinoid, developed to overcome all-trans retinoic acid (ATRA) resistance, with potential antineoplastic

Formula: C₂₂H₂₅NO₃

Purity: 98.55% - 99.73%

Color and Shape: Crystalline Solid

Molecular weight: 351.44

Ref: TM-T6694

4-((5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbamoyl)benzoic acid

CAS: 94497-51-5

Purity: 95.0%

Color and Shape: Solid

Molecular weight: 351.4460144042969

Ref: 10-F079395

Tamibarotene

Controlled Product

CAS: 94497-51-5

Applications Synthetic retinoic acid receptor-α/β-selective retinoid. Antineoplastic.
References Hashimoto, Y., et al.: Jpn. J. Cancer Res., 79, 473 (1988), Mizojiri, K., et al.: Arzneim.-Forsch., 47, 59 (1997), Shinjo, K., et al.: Int. J. Hematol., 72, 470 (2000), Sanda, T., et al.: Leukemia, 19, 901 (2005),

Formula: C₂₂H₂₅NO₃

Color and Shape: Neat

Molecular weight: 351.44

Ref: TR-T005800

Tamibarotene

CAS: 94497-51-5

Retinoic acid receptor alpha agonist; antineoplastic

Formula: C₂₂H₂₅NO₃

Purity: Min. 95%

Molecular weight: 351.44 g/mol

Ref: 3D-FT27993