CAS 94535-16-7

3-Methylether-estradiol

Description:

3-Methylether-estradiol, also known by its CAS number 94535-16-7, is a synthetic derivative of estradiol, which is a primary female sex hormone. This compound features a methoxy group at the 3-position of the estradiol structure, which alters its biological activity and pharmacokinetics compared to natural estradiol. It is characterized by its potential estrogenic activity, making it relevant in the field of hormone replacement therapy and contraceptive formulations. The presence of the methoxy group can enhance its lipophilicity, affecting its absorption and distribution in biological systems. Additionally, 3-Methylether-estradiol may exhibit different binding affinities to estrogen receptors, influencing its efficacy and side effect profile. As with many synthetic hormones, its use must be carefully managed to mitigate potential risks associated with hormone therapy, such as thromboembolic events or hormone-sensitive cancers. Overall, 3-Methylether-estradiol represents an important compound in medicinal chemistry, particularly in the development of therapeutic agents targeting estrogen-related conditions.

Formula: C₁₉H₂₆O₂

InChI: InChI=1/C19H26O2/c1-19-10-9-15-14-6-4-13(21-2)11-12(14)3-5-16(15)17(19)7-8-18(19)20/h4,6,11,15-18,20H,3,5,7-10H2,1-2H3

SMILES: CC12CCC3c4ccc(cc4CCC3C1CCC2O)OC

Synonyms:

• 17b-Estradiol 3-methyl ether
• 3-Methoxyestra-1,3,5(10)-Trien-17-Ol

3-Methylether-estradiol

Controlled Product

CAS: 94535-16-7

3-Methylether-estradiol is a naturally occurring estrogen that is found in humans and other mammals. It binds to estrogen receptors on the plasma membrane, which stimulates cell growth, protein synthesis, and modulates the immune system. 3-Methylether-estradiol has been shown to inhibit taurocholic acid induced hypertension in rats by blocking the conversion of angiotensin I to angiotensin II. In addition, this compound has been shown to have anti-inflammatory properties and can be used as an antihypertensive agent. 3-Methylether-estradiol has also been shown to increase blood pressure in pregnant rats when given at bolus doses. This drug should not be prescribed for use during pregnancy because it can cause fetal death.

Formula: C₁₉H₂₆O₂

Purity: Min. 95%

Molecular weight: 286.41 g/mol

Ref: 3D-FM148485