CAS 945419-64-7

Propanamide, N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfinyl]-2-hydroxy-2-methyl-

Description:

Propanamide, N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfinyl]-2-hydroxy-2-methyl- is a chemical compound characterized by its complex structure, which includes an amide functional group, a cyano group, and a trifluoromethyl group, along with a sulfinyl moiety and a hydroxyl group. This compound is likely to exhibit polar characteristics due to the presence of the hydroxyl and cyano groups, which can engage in hydrogen bonding and dipole-dipole interactions. The trifluoromethyl and fluorophenyl groups contribute to its lipophilicity and may influence its reactivity and solubility in organic solvents. The sulfinyl group can also impart unique electronic properties, potentially affecting the compound's biological activity. Given its structural complexity, this compound may be of interest in pharmaceutical research or materials science, particularly in the development of novel therapeutic agents or functional materials. Its specific properties, such as melting point, boiling point, and solubility, would require empirical measurement or detailed computational analysis for precise characterization.

Formula: C₁₈H₁₄F₄N₂O₃S

Synonyms:

• Bicalutamide Impurity 7(EP Impurity E)
• N-[4-Amido-3-(trifluoromethyl)phenyl-3-[(4-fluorophenyl)-(R,S)-sulphinyl]-(R,S)-2-hydroxy-2-methylpropanamide
• Bicalutamide USP RC A
• Bicalutamide USP Related Compound A
• Bicalutamide Sulfoxide
• Bicalutamide EP Impurity E (USP RC A)
• rel-(R*,S*)-BicalutaMide Sulfoxide
• Propanamide, N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfinyl]-2-hydroxy-2-methyl-
• Bicalutamide Impurity 7

N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfinyl]-2-hydroxy-2-methylpropanamide

CAS: 945419-64-7

Color and Shape: Neat

Ref: 86-MM0894.01

Bicalutamide Sulfoxide (Bicalutamide USP Related Compound A)

CAS: 945419-64-7

Formula: C₁₈H₁₄F₄N₂O₃S

Color and Shape: White To Off-White Solid

Molecular weight: 414.38

Ref: 4Z-B-0210

Bicalutamide USP Related Compound A

CAS: 945419-64-7

Formula: C₁₈H₁₄F₄N₂O₃S

Molecular weight: 414.37

Ref: ST-EA-CP-B12019

N-[4-Amido-3-(trifluoromethyl)phenyl-3-[(4-fluorophenyl)-(R,S)-sulphinyl]-(R,S)-2-hydroxy-2-methylpropanamide

CAS: 945419-64-7

N-[4-Amino-3-(trifluoromethyl)phenyl-3-[(4-fluorophenyl)-(R,S)-sulphinyl]- (R,S)-2-hydroxy-2-methylpropanamide is a sulfoxide that was designed to inhibit cancer cell proliferation. It has been shown to have anticancer activity in different models. The synthesis of this compound begins with the chlorination of 4-aminophenol, which produces 4-(chloromethyl)benzenesulfonyl chloride. This is then reacted with (R,S)-α-(4-Fluorophenyl)acetic acid and the resulting product is purified by column chromatography to give N-[4-(chloromethyl)phenyl]-3-[(4-fluorophenyl)(R,S)-sulphinyl]propaneamide. The final step in the synthesis is achieved by reacting the amide

Formula: C₁₈H₁₄F₄N₂O₃S

Purity: Min. 95%

Color and Shape: White To Off-White Solid

Molecular weight: 414.37 g/mol

Ref: 3D-IA58276

Bicalutamide Sulfoxide

Controlled Product

CAS: 945419-64-7

Impurity Bicalutamide USP Related Compound A
Applications Bicalutamide Sulfoxide is a derivative of Bicalutamide (B382000), non-steroidal peripherally active antiandrogen. Used as an antiandrogen, antineoplastic (hormonal).
References Tucker, H., et al.: J. Med. Chem., 31, 954 (1988), Cockshott, I.D., et al.: Eur. Urol., 18, Suppl. 3, 10 (1990), Cockshott, I., et al.: Br. J. Clin. Pharm., 36, 339 (1993), McKillop, D., et al.: Xenobiotica, 25, 623 (1995),

Formula: C₁₈H₁₄F₄N₂O₃S

Color and Shape: Neat

Molecular weight: 414.37

Ref: TR-B382055