CAS 945553-91-3

R-afatinib

Description:

R-afatinib is a small molecule tyrosine kinase inhibitor primarily used in the treatment of certain types of non-small cell lung cancer (NSCLC) that harbor specific mutations in the epidermal growth factor receptor (EGFR). It is an irreversible inhibitor that targets multiple members of the ErbB family of receptors, including EGFR, HER2, and HER4, thereby disrupting signaling pathways that promote tumor growth and survival. R-afatinib is characterized by its ability to bind covalently to the active site of these kinases, leading to prolonged inhibition compared to reversible inhibitors. The compound is typically administered orally and has a favorable pharmacokinetic profile, allowing for once-daily dosing. Common side effects may include diarrhea, rash, and stomatitis, which are associated with its mechanism of action. R-afatinib's efficacy is particularly noted in patients with specific EGFR mutations, making it a targeted therapy option in personalized cancer treatment. Its development represents a significant advancement in the management of EGFR-mutant NSCLC.

Formula: C₂₄H₂₅ClFN₅O₃

Synonyms:

• (E)-N-[4-(3-chloro-4-fluoroanilino)-7-[(3R)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide
• but-2-enamide
• Afatinib impurity 3/R-afatinib/(2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3R)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide
• 2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3R)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-, (2E)-
• Afatinib-2
• hydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)
• (R,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide? (Afatinib Impurity）
• afatinib impurities139
• 2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3R)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-
• (R,E)-N-(4-((3-Chloro-4- fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinozolin- 6-yl)-4-(dimethylamino)but-2-enamide
• AFATINIB CHIRAL IMPURITY
• (R,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetra-

(R,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide

CAS: 945553-91-3

Formula: C₂₄H₂₅ClFN₅O₃

Purity: 98%

Molecular weight: 485.9384

Ref: IN-DA00JSCQ

(R,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide (Afatinib Impurity)

CAS: 945553-91-3

(R,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide (Afatinib Impurity）

Purity: 98%

Molecular weight: 485.94g/mol

Ref: 54-PC109919

(R)-Afatinib ((R)-BIBW 2992)

CAS: 945553-91-3

Formula: C₂₄H₂₅ClFN₅O₃

Color and Shape: Pale Yellow Solid

Molecular weight: 485.94

Ref: 4Z-A-111006

(R,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide

CAS: 945553-91-3

Purity: 99.0%

Molecular weight: 485.94000244140625

Ref: 10-F549748

(R)-Afatinib

Controlled Product

CAS: 945553-91-3

Applications (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3R)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide, is an impurity of Afatinib (A355300) an aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.

Formula: C₂₄H₂₅ClFN₅O₃

Color and Shape: Neat

Molecular weight: 485.94

Ref: TR-C597485

Afatinib Impurity C

CAS: 945553-91-3

Formula: C₂₄H₂₅ClFN₅O₃

Molecular weight: 486

Ref: ST-EA-CP-A50003