CAS 945667-22-1

Saxagliptin hydrate

Description:

Saxagliptin hydrate is a pharmaceutical compound primarily used as an antidiabetic medication, specifically for the management of type 2 diabetes mellitus. It functions as a dipeptidyl peptidase-4 (DPP-4) inhibitor, which helps to increase insulin secretion and decrease glucagon levels in the bloodstream, thereby improving glycemic control. The substance appears as a white to off-white crystalline powder and is soluble in water, making it suitable for oral administration. Its molecular formula includes a specific arrangement of carbon, hydrogen, nitrogen, and oxygen atoms, contributing to its biological activity. Saxagliptin hydrate is typically administered in tablet form and may be used alone or in combination with other antidiabetic agents. As with any medication, it is essential to consider potential side effects, contraindications, and interactions with other drugs. The compound's stability and efficacy are influenced by factors such as pH and temperature, which are critical in pharmaceutical formulations.

Formula: C₁₈H₂₅N₃O₂·H₂O

InChI: InChI=1S/C18H25N3O2.H2O/c19-8-13-2-12-3-14(12)21(13)16(22)15(20)17-4-10-1-11(5-17)7-18(23,6-10)9-17;/h10-15,23H,1-7,9,20H2;1H2/t10?,11?,12-,13+,14+,15-,17?,18?;/m1./s1

InChI key: InChIKey=AFNTWHMDBNQQPX-NHKADLRUSA-N

SMILES: [C@H](C(=O)N1[C@@]2([C@@](C2)(C[C@H]1C#N)[H])[H])(N)C34CC5(O)CC(C3)CC(C4)C5.O

Synonyms:

• (1S,3S,5S)-2-((2S)-2-Amino-2-(3-Hydroxytricyclo(3.3.1.13,7)Dec-1-Yl)Acetyl)-2-Azabicyclo(3.1.0)Hexane-3-Carbonitrile Hydrate
• 2-Azabicyclo[3.1.0]hexane-3-carbonitrile, 2-[(2S)-2-amino-2-(3-hydroxytricyclo[3.3.1.1^3,7]dec-1-yl)acetyl]-, hydrate (1:1), (1S,3S,5S)-
• Saxagliptin hydrate
• 2-Azabicyclo[3.1.0]hexane-3-carbonitrile, 2-[(2S)-2-amino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-, hydrate (1:1), (1S,3S,5S)-
• Saxagliptin monohydrate
• BMS-477118 HYDRATE;BMS 477118 HYDRATE;BMS477118 HYDRATE
• (1S,3S,5S)-2-((2S)-2-amino-2-(3-hydroxyadamantan-1-yl)acetyl)-2-azabicyclo[3.1.0]hexane-3-carbonitrile hydrate
• Saxagliptin hydrate (BMS-477118 hydrate)
• Unii-9gb927lajw
• BMS 477118 hydrate
• BMS-477118 hydrate
• BMS477118 hydrate
• Onglyza hydrate
• (1S,3S,5S)-2-[(2S)-2-Amino-2-(3-hydroxytricyclo[3.3.1.1(3,7)]dec-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile hydrate

SAXAGLIPTIN IMPURITY MIXTURE CRS

CAS: 945667-22-1

SAXAGLIPTIN IMPURITY MIXTURE CRS

Ref: 41-Y0002360

SAXAGLIPTIN MONOHYDRATE CRS

CAS: 945667-22-1

SAXAGLIPTIN MONOHYDRATE CRS

Ref: 41-Y0002369

Saxagliptin

CAS: 945667-22-1

Heterocyclic compounds with nitrogen hetero-atom(s) only, excluding aromatic or modified aromatic

Formula: C₁₈H₂₅N₃O₂·H₂O

Color and Shape: White Off-White Light Brown Crystalline Powder

Molecular weight: 333.20524

Ref: 45-1609862

(1S,3S,5S)-2-[(2S)-2-Amino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile hydrate(1:1)

CAS: 945667-22-1

Formula: C₁₈H₂₇N₃O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 333.4253

Ref: IN-DA003A9U

Saxagliptin hydrate

CAS: 945667-22-1

Saxagliptin hydrate (Onglyza hydrate) is a selective and reversible DPP4 inhibitor (IC50: 26 nM; Ki: 1.3 nM).

Formula: C₁₈H₂₅N₃O₂·H₂O

Purity: 99.52%

Color and Shape: Solid

Molecular weight: 333.43

Ref: TM-T0178

Saxagliptin Hydrate

CAS: 945667-22-1

Saxagliptin Hydrate

Purity: 98%

Molecular weight: 333.43g/mol

Ref: 54-OR1026542

Saxagliptin hydrate

CAS: 945667-22-1

Saxagliptin hydrate

Purity: ≥98%

Molecular weight: 333.43g/mol

Ref: 54-BUP13586

Saxagliptin Hydrate

Controlled Product

CAS: 945667-22-1

Applications Saxagliptin Hydrate is a selective and reversible dipeptidyl peptidase-4 (DPP4) inhibitor that may be used to develop treatment for type 2 diabetes.
References Gu, S., et al.: PLoS One. 11, e0167190 (2016); Dave, D. J.: J Pharmacol Pharmacother 2, 230 (2011)

Formula: C₁₈H₂₅N₃O₂·H₂O

Color and Shape: Neat

Molecular weight: 333.43

Ref: TR-S143750

Saxagliptin monohydrate

CAS: 945667-22-1

Dipeptidyl peptidase-4 inhibitor; anti-diabetic agent

Formula: C₁₈H₂₅N₃O₂•H₂O

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 333.43 g/mol

Ref: 3D-FS44431