CAS 946128-88-7

RO5126766(CH5126766)

Description:

RO5126766, also known as CH5126766, is a chemical compound that belongs to the class of small molecules and is primarily recognized for its role as a selective inhibitor of certain kinases, particularly those involved in cancer signaling pathways. It has garnered attention in pharmaceutical research due to its potential therapeutic applications, particularly in oncology. The compound exhibits a specific mechanism of action that targets and modulates the activity of proteins involved in cell proliferation and survival, making it a candidate for cancer treatment. Its chemical structure includes functional groups that contribute to its binding affinity and selectivity for its target kinases. Additionally, RO5126766 has been studied for its pharmacokinetic properties, including absorption, distribution, metabolism, and excretion (ADME), which are crucial for determining its efficacy and safety profile in clinical settings. As with many investigational drugs, ongoing research is essential to fully understand its biological effects and therapeutic potential.

Formula: C₂₁H₁₈FN₅O₅S

Synonyms:

• RO5126766(CH5126766) 3-[[2-[(Methylaminosulfonyl)amino]-3-fluoropyridin-4-yl]methyl]-4-methyl-7-[(pyrimidin-2-yl)oxy]-2H-1-benzopyran-2-one
• 3-{2-(methylaminosulfonyl)amino-3-fluoropyridin-4-ylmethyl}-4-methyl-7-(pyrimidin-2-yloxy)-2-oxo-2H-1-benzopyran
• Sulfamide, N-[3-fluoro-4-[[4-methyl-2-oxo-7-(2-pyrimidinyloxy)-2H-1-benzopyran-3-yl]methyl]-2-pyridinyl]-N'-methyl-
• CH5126766
• CS-1469
• RO5126766(CH5126766)
• 3-[[2-[(Methylaminosulfonyl)amino]-3-fluoropyridin-4-yl]methyl]-4-methyl-7-[(pyrimidin-2-yl)oxy]-2H-1-benzopyran-2-one

3-[[2-[(Methylaminosulfonyl)amino]-3-fluoropyridin-4-yl]methyl]-4-methyl-7-[(pyrimidin-2-yl)oxy]-2H-1-benzopyran-2-one

CAS: 946128-88-7

Formula: C₂₁H₁₈FN₅O₅S

Purity: 98%

Color and Shape: Solid

Molecular weight: 471.4615

Ref: IN-DA01EEGS

Ro 5126766

CAS: 946128-88-7

Ro 5126766

Purity: ≥98%

Molecular weight: 471.46g/mol

Ref: 54-BUP03418

Ro 5126766

CAS: 946128-88-7

RO5126766 (CH5126766) is a dual RAF/MEK inhibitor with IC50 of 8.2 nM, 19 nM, 56 nM, and 160 nM for BRAF V600E, BRAF, CRAF, and MEK1, respectively. Phase 1.

Formula: C₂₁H₁₈FN₅O₅S

Purity: 98.3% - 98.81%

Color and Shape: Solid

Molecular weight: 471.46

Ref: TM-T6971

Ro 5126766

CAS: 946128-88-7

Inhibitor of MEK1 and MEK2 kinases

Formula: C₂₁H₁₈FN₅O₅S

Purity: Min. 95%

Molecular weight: 471.46 g/mol

Ref: 3D-FR103619