CAS 947527-73-3

Vincaleukoblastine, 22-oxo-, 6′-oxide

Description:

Vincaleukoblastine, 22-oxo-, 6′-oxide, identified by its CAS number 947527-73-3, is a chemical compound that belongs to the class of alkaloids derived from the periwinkle plant, Vinca rosea. This compound is structurally related to vincristine and vinblastine, which are known for their antitumor properties. Vincaleukoblastine exhibits characteristics typical of vinca alkaloids, including the ability to inhibit microtubule formation, thereby disrupting mitotic spindle function during cell division. This mechanism makes it a subject of interest in cancer research and chemotherapy. The compound may also possess various pharmacological activities, including potential effects on cell proliferation and apoptosis. Its chemical structure features specific functional groups that contribute to its biological activity and solubility properties. As with many alkaloids, vincaleukoblastine may exhibit toxicity, necessitating careful handling and consideration in therapeutic applications. Further studies are essential to fully elucidate its pharmacokinetics, efficacy, and safety profile in clinical settings.

Formula: C₄₆H₅₆N₄O₁₁

InChI: InChI=1S/C46H56N4O11/c1-7-42(55)22-28-23-45(40(53)59-5,36-30(14-19-50(57,24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)58-4)49(26-51)38-44(31)16-18-48-17-11-15-43(8-2,37(44)48)39(61-27(3)52)46(38,56)41(54)60-6/h9-13,15,20-21,26,28,37-39,47,55-56H,7-8,14,16-19,22-25H2,1-6H3/t28-,37-,38+,39+,42-,43+,44+,45-,46-,50-/m0/s1

InChI key: InChIKey=RMXAXRWGUNEVQR-FFFVJEPASA-N

SMILES: C(C)[C@@]12[C@]3([C@@]4([C@]([C@](C(OC)=O)(O)[C@@H]1OC(C)=O)(N(C=O)C=5C4=CC(=C(OC)C5)[C@]6(C(OC)=O)C7=C(C=8C(N7)=CC=CC8)CCN9(=O)C[C@](C6)(C[C@](CC)(O)C9)[H])[H])CCN3CC=C2)[H]

Synonyms:

• Vincaleukoblastine, 22-oxo-, 6′-oxide

Vincristine Impurity 5

CAS: 947527-73-3

Formula: C₄₆H₅₆N₄O₁₁

Molecular weight: 840.97

Ref: 4Z-V-196

Vincristine N-oxide

CAS: 947527-73-3

Molecular weight: 840.96

Ref: 7W-GP9804

Vincristine N-Oxide

CAS: 947527-73-3

Applications Potential treatment for hyperproliferative disorders

Formula: C₄₆H₅₆N₄O₁₁

Color and Shape: Neat

Molecular weight: 840.96

Ref: TR-V314100

22-Oxo-vincaleukoblastine 6'-oxide

CAS: 947527-73-3

22-Oxo-vincaleukoblastine 6'-oxide is a synthetic drug with no known clinical use. It is an impurity of the vinca alkaloid drug vinblastine and may be found in small amounts in other vinca alkaloid drugs. 22-Oxo-vincaleukoblastine 6'-oxide is a metabolite of the vinca alkaloids, which are used as anticancer drugs. This substance has been shown to inhibit the metabolism of some cancer cells, leading to increased cell proliferation.

Formula: C₄₆H₅₆N₄O₁₁

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 840.96 g/mol

Ref: 3D-IO28695