CAS 94825-44-2

Guanosine 5′-(trihydrogen diphosphate), P′-anhydride with phosphorothioic acid, lithium salt (1:4)

Description:

Guanosine 5′-(trihydrogen diphosphate), P′-anhydride with phosphorothioic acid, lithium salt (1:4), identified by CAS number 94825-44-2, is a chemical compound that features a guanosine moiety linked to a diphosphate group, which is further modified by the presence of phosphorothioic acid. This compound is characterized by its role in biochemical processes, particularly in nucleotide metabolism and signaling pathways. The lithium salt form indicates that lithium ions are associated with the molecule, potentially influencing its solubility and reactivity. The presence of phosphorothioate groups suggests enhanced stability against enzymatic degradation, making it of interest in molecular biology and therapeutic applications. Additionally, the compound may exhibit unique properties such as altered binding affinities and biological activities compared to its non-thiophosphate counterparts. Overall, this compound represents a significant tool in biochemical research, particularly in studies involving nucleotides and their analogs.

Formula: C₁₀H₁₇LiN₅O₁₃P₃S

InChI: InChI=1/C10H16N5O13P3S.4Li/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(26-9)1-25-29(19,20)27-30(21,22)28-31(23,24)32;;;;/h2-3,5-6,9,16-17H,1H2,(H,19,20)(H,21,22)(H2,23,24,32)(H3,11,13,14,18);;;;/q;4*+1/p-4/t3-,5-,6-,9-;;;;/m1..../s1

InChI key: InChIKey=AJURWUWKKPDAFD-ZVQJTLEUSA-N

SMILES: O[C@H]1[C@H](N2C3=C(N=C2)C(=O)N=C(N)N3)O[C@H](COP(OP(OP(=O)(O)S)(=O)O)(=O)O)[C@H]1O.[Li]

Synonyms:

• Guanosine 5-O-(3-Thiotriphosphate), Tetralithium Salt
• Guanosine 5′-(trihydrogen diphosphate), P′-anhydride with phosphorothioic acid, lithium salt (1:4)
• Guanosine 5′-(trihydrogen diphosphate), P′-anhydride with phosphorothioic acid, tetralithium salt
• tetralithium 5'-O-[({[(dioxidophosphorothioyl)oxy]phosphinato}oxy)phosphinato]guanosine
• Guanosine 5-[gamma-thio]triphosphate tetralithium salt
• GTP-GAMMA-S TETRALITHIUM
• guanosine 5'-[γ-thio]triphosphate tetralithium salt
• gtp-γ-s-li4
• Guanosine 5'-[γ-thio]triphosphate (lithium salt)
• GTP-GAMMA-S-LI4
• Guanosine 5-O-(3-Thiotriphosphate), Tetralithium Salt - CAS 94825-44-2 - Calbiochem
• GUANOSINE 5'-(TRIHYDROGEN DIPHOSPHATE), MONOANHYDRIDE WITH PHOSPHOROTHIOIC ACID, TETRALITHIUM
• GTP-GAMMA-S TETRALITHIUM SALT
• GTP-GAMMA-S 4LI
• Guanosine 5'-O-(3-Thiodiphosphate) Tetralithium Salt
• GUANOSINE-5'-O-(3-THIOTRIPHOSPHORIC ACID), TETRALITHIUM
• Guanosine 5′-[γ-thio]triphosphate
• GTPγS tetralithium salt
• GUANOSINE-5'-O-(3-THIOTRIPHOSPHATE) TETRALITHIUM
• [[(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl] dioxidophosphinothioyl phosphate
• Guanosine-5''-O-(3-thiotriphosphoric acid) tetralithium salt
• Guanosine-5'-(γ-thiotriphosphoric acid α,β,γ,γ-tetrakislithium) salt
• Guanosine 5'-(γ-thiotriphosphoric acid)tetralithium salt
• Guanosine 5'-(trihydrogen diphosphate), monoanhydride with phosphorothioic acid, tetralithium salt

Guanosine 5'-[γ-thio]triphosphate (lithium salt)

CAS: 94825-44-2

Formula: C₁₀H₁₆LiN₅O₁₃P₃S

Purity: 90%

Color and Shape: Solid

Molecular weight: 546.1870

Ref: IN-DA005V2I

GTPγS tetralithium

CAS: 94825-44-2

GTPγS tetralithium

Purity: ≥70%

Molecular weight: 562.98g/mol

Ref: 54-BUP21702

Guanosine 5''-[γ-thio]triphosphate tetralithium salt

CAS: 94825-44-2

Formula: C₁₀H₁₂Li₄N₅O₁₃P₃S

Purity: ≥ 80.0%

Color and Shape: White to off-white powder

Molecular weight: 562.98

Ref: 7W-GL6795

Guanosine 5'-[γ-thio]triphosphate tetralithium

CAS: 94825-44-2

Guanosine 5'-[γ-thio]triphosphate tetralithium (GTPγS) is a guanine nucleotide analog that has been shown to modulate the signal transduction pathway in many types of cells. GTPγS activates the extracellular signal-transducing receptor kinase and phospholipase C, which are involved in cellular proliferation and differentiation. This agent also blocks calcium channels, thereby inhibiting neuromuscular transmission. It has been shown to be effective against pertussis toxin and other agents that block G protein coupling by inhibiting adenylate cyclase. In addition, GTPγS inhibits staurosporin-sensitive K+ channels in some neuronal cells, but not those that are insensitive to this blocker.

Formula: C₁₀H₁₂Li₄N₅O₁₃P₃S

Purity: Min. 90 Area-%

Color and Shape: Powder

Molecular weight: 562.98 g/mol

Ref: 3D-NG63193

GTPγS tetralithium

CAS: 94825-44-2

GTPγS tetralithium (Guanosine 5'-[γ-thio]triphosphate tetralithium) is a G-protein activator and a non-hydrolyzable GTP analog.

Formula: C₁₀H₁₂Li₄N₅O₁₃P₃S

Purity: 75%

Color and Shape: Solid

Molecular weight: 562.98

Ref: TM-T82252