CAS 94991-73-8
:(-)-Mexiletine
Description:
(-)-Mexiletine is a pharmaceutical compound primarily used as an antiarrhythmic agent, particularly for the treatment of ventricular arrhythmias. It is a chiral molecule, with the (-) designation indicating its specific stereochemistry, which is crucial for its biological activity. The compound is classified as an aromatic ether and is structurally related to lidocaine, sharing similar mechanisms of action by blocking sodium channels in cardiac tissues, thereby stabilizing the cardiac membrane and reducing excitability. (-)-Mexiletine is typically administered orally and is known for its relatively rapid absorption and bioavailability. Its pharmacokinetics can be influenced by factors such as liver metabolism and individual patient characteristics. Common side effects may include gastrointestinal disturbances, dizziness, and potential central nervous system effects. Due to its specific action on cardiac tissues, (-)-Mexiletine is particularly valuable in managing certain types of arrhythmias, but it requires careful monitoring to avoid adverse effects and interactions with other medications.
Formula:C11H17NO
InChI:InChI=1S/C11H17NO/c1-8-5-4-6-9(2)11(8)13-7-10(3)12/h4-6,10H,7,12H2,1-3H3/t10-/m1/s1
InChI key:InChIKey=VLPIATFUUWWMKC-SNVBAGLBSA-N
SMILES:O(C[C@@H](C)N)C1=C(C)C=CC=C1C
Synonyms:- 2-Propanamine, 1-(2,6-dimethylphenoxy)-, (2R)-
- (R)-(-)-Mexiletine
- l-Mexiletine
- (2R)-1-(2,6-Dimethylphenoxy)-2-propanamine
- 2-Propanamine, 1-(2,6-dimethylphenoxy)-, (R)-
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