α-Gemcitabine, with the CAS number 95058-85-8, is a nucleoside analog that is primarily used in cancer therapy. It is a derivative of cytidine and functions as an antimetabolite, inhibiting DNA synthesis and repair, which is crucial for the proliferation of cancer cells. The compound is characterized by its ability to mimic natural nucleosides, allowing it to be incorporated into DNA during replication. This incorporation leads to chain termination and ultimately induces apoptosis in rapidly dividing cells. α-Gemcitabine is typically administered intravenously and is known for its effectiveness against various types of cancers, including pancreatic, lung, and bladder cancers. Its pharmacokinetics involve rapid cellular uptake and metabolism, with a relatively short half-life in circulation. Side effects may include myelosuppression, gastrointestinal disturbances, and fatigue, which are common with many chemotherapeutic agents. Overall, α-Gemcitabine represents a significant advancement in targeted cancer treatment, showcasing the importance of nucleoside analogs in modern oncology.

α-Gemcitabine

95058-85-8: α-Gemcitabine, with the CAS number 95058-85-8, is a nucleoside analog that is primarily used in cancer therapy. It is a derivative of cytidine and functions as an antimetabolite, inhibiting DNA synthesis and repair, which is crucial for the proliferation of cancer cells. The compound is characterized by its ability to mimic natural nucleosides, allowing it to be incorporated into DNA during replication. This incorporation leads to chain termination and ultimately induces apoptosis in rapidly dividing cells. α-Gemcitabine is typically administered intravenously and is known for its effectiveness against various types of cancers, including pancreatic, lung, and bladder cancers. Its pharmacokinetics involve rapid cellular uptake and metabolism, with a relatively short half-life in circulation. Side effects may include myelosuppression, gastrointestinal disturbances, and fatigue, which are common with many chemotherapeutic agents. Overall, α-Gemcitabine represents a significant advancement in targeted cancer treatment, showcasing the importance of nucleoside analogs in modern oncology.

CAS 95058-85-8

α-Gemcitabine

Gemcitabine EP Impurity B

Ref: ST-EA-CP-G7002