Timapiprant sodium is a chemical compound that functions primarily as a selective antagonist of the prostaglandin D2 receptor subtype 2 (DP2). It is often investigated for its potential therapeutic applications, particularly in the treatment of allergic conditions and asthma, due to its ability to inhibit the action of prostaglandin D2, a mediator involved in inflammatory responses. The compound is characterized by its sodium salt form, which enhances its solubility in aqueous solutions, making it suitable for various pharmaceutical formulations. Timapiprant sodium is typically administered in a controlled dosage to ensure efficacy while minimizing side effects. Its pharmacokinetic properties, including absorption, distribution, metabolism, and excretion, are crucial for determining its therapeutic profile. As with many pharmaceutical compounds, ongoing research continues to explore its full potential and safety profile in clinical settings. Overall, Timapiprant sodium represents a significant advancement in the development of targeted therapies for managing allergic and inflammatory diseases.

Timapiprant, also known as OC000459, is a potent, selective and orally active CRTH2 antagonist. OC000459 reduces nasal and ocular symptoms in allergic subjects exposed to grass pollen, a randomised, placebo-controlled, double-blind trial.  OC000459 inhibits mast cell-dependent activation of T helper 2 lymphocytes and eosinophils. OC000459 treatment inhibited LAR and post-allergen increase in sputum eosinophils. OC000459 appears to inhibit allergic inflammation in asthma.

Timapiprant sodium

950688-14-9: Timapiprant sodium is a chemical compound that functions primarily as a selective antagonist of the prostaglandin D2 receptor subtype 2 (DP2). It is often investigated for its potential therapeutic applications, particularly in the treatment of allergic conditions and asthma, due to its ability to inhibit the action of prostaglandin D2, a mediator involved in inflammatory responses. The compound is characterized by its sodium salt form, which enhances its solubility in aqueous solutions, making it suitable for various pharmaceutical formulations. Timapiprant sodium is typically administered in a controlled dosage to ensure efficacy while minimizing side effects. Its pharmacokinetic properties, including absorption, distribution, metabolism, and excretion, are crucial for determining its therapeutic profile. As with many pharmaceutical compounds, ongoing research continues to explore its full potential and safety profile in clinical settings. Overall, Timapiprant sodium represents a significant advancement in the development of targeted therapies for managing allergic and inflammatory diseases.

Timapiprant sodium: potent DP2 antagonist; inhibits mast cell activation; displaces [3H]PGD2, Ki=3-13 nM.

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CAS 950688-14-9

Timapiprant sodium

Timapiprant sodium

Ref: TM-T17099

Timapiprant sodium

Ref: 3D-ANB68814