CAS 95094-00-1
:(-)-Carvedilol
Description:
(-)-Carvedilol is a non-selective beta-adrenergic antagonist with additional alpha-1 blocking properties, primarily used in the management of hypertension and heart failure. It is classified as a racemic mixture, but the (-)-enantiomer is the more pharmacologically active form. The compound exhibits a unique dual mechanism of action, which helps in reducing heart rate and lowering blood pressure while also providing antioxidant effects. Chemically, it is characterized by a chiral center, which contributes to its stereochemistry and biological activity. The molecular structure includes a phenolic hydroxyl group, a propanolamine side chain, and a substituted aromatic ring, which are crucial for its binding to adrenergic receptors. (-)-Carvedilol is typically administered orally and is well-absorbed, with a bioavailability that can be influenced by first-pass metabolism. Its therapeutic effects are often accompanied by side effects such as fatigue, dizziness, and gastrointestinal disturbances. Overall, (-)-Carvedilol is an important medication in cardiovascular therapy, offering benefits beyond simple blood pressure reduction.
Formula:C24H26N2O4
InChI:InChI=1S/C24H26N2O4/c1-28-21-10-4-5-11-22(21)29-14-13-25-15-17(27)16-30-23-12-6-9-20-24(23)18-7-2-3-8-19(18)26-20/h2-12,17,25-27H,13-16H2,1H3/t17-/m0/s1
InChI key:InChIKey=OGHNVEJMJSYVRP-KRWDZBQOSA-N
SMILES:O(C[C@H](CNCCOC1=C(OC)C=CC=C1)O)C2=C3C=4C(NC3=CC=C2)=CC=CC4
Synonyms:- 2-Propanol, 1-(9H-carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-, (S)-
- (S)-Carvedilol
- 2-Propanol, 1-(9H-carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-, (2S)-
- (S)-(-)-Carvedilol
- (2S)-1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol
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Found 7 products.
(2s)-1-(9h-carbazol-4-yloxy)-3-{[2-(2-methoxyphenoxy)ethyl]amino}propan-2-ol
CAS:Formula:C24H26N2O4Purity:98%Color and Shape:SolidMolecular weight:406.4742(2s)-1-(9h-carbazol-4-yloxy)-3-{[2-(2-methoxyphenoxy)ethyl]amino}propan-2-ol
CAS:Purity:98%Molecular weight:406.482(S)-(-)-Carvedilol
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications The optically active isomer of Carvedilol (C184625), a nonselective ß-adrenergic blocker with a1-blocking activity. An antihypertensive used in the treatment of congestive heart failure.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hirohashi, M., et al.: Arzneim.-Forsch., 40, 735 (1990),<br></p>Formula:C24H26N2O4Color and Shape:Off White SolidMolecular weight:406.47(S)-Carvedilol
CAS:<p>(S)-Carvedilol is a non-selective β/α-1 blocker.It exerts protection against the vascular or cardiac toxicity of Doxorubicin (DOX).</p>Formula:C24H26N2O4Purity:98%Color and Shape:Less Crystalline Solid Colourless Crystalline SolidMolecular weight:406.47
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