CAS 951395-08-7

Tafamidis meglumine

Description:

Tafamidis meglumine is a pharmaceutical compound primarily used in the treatment of transthyretin amyloidosis, a condition characterized by the accumulation of amyloid proteins in various tissues. It acts as a stabilizer of the transthyretin protein, preventing its misfolding and subsequent amyloid formation. The substance is a salt form of tafamidis, which enhances its solubility and bioavailability. Tafamidis meglumine is typically administered orally and has been shown to improve functional outcomes and quality of life in patients with this rare disease. The compound is characterized by its specific molecular structure, which includes a core aromatic system that contributes to its binding affinity for transthyretin. Its pharmacokinetics indicate a favorable absorption profile, with a relatively long half-life, allowing for once-daily dosing. As with any medication, potential side effects may include gastrointestinal disturbances and other reactions, necessitating careful monitoring during treatment. Overall, tafamidis meglumine represents a significant advancement in the management of transthyretin amyloidosis.

Formula: C₁₄H₇Cl₂NO₃·C₇H₁₇NO₅

InChI: InChI=1S/C14H7Cl2NO3.C7H17NO5/c15-9-3-8(4-10(16)6-9)13-17-11-2-1-7(14(18)19)5-12(11)20-13;1-8-2-4(10)6(12)7(13)5(11)3-9/h1-6H,(H,18,19);4-13H,2-3H2,1H3/t;4-,5+,6+,7+/m.0/s1

InChI key: InChIKey=DQJDBUPLRMRBAB-WZTVWXICSA-N

SMILES: ClC=1C=C(C=2OC=3C(N2)=CC=C(C(O)=O)C3)C=C(Cl)C1.[C@H]([C@@H]([C@@H](CO)O)O)([C@H](CNC)O)O

Synonyms:

• Vyndaqel
• Fx 1006A
• Tafamidis meglumine
• D-Glucitol, 1-deoxy-1-(methylamino)-, 2-(3,5-dichlorophenyl)-6-benzoxazolecarboxylate (1:1)

Tafamidis Meglumine

CAS: 951395-08-7

Formula: C₁₄H₇Cl₂NO₃·C₇H₁₇NO₅

Molecular weight: 308.11 195.22

Ref: 4Z-T-302004

tafamidis meglumine

CAS: 951395-08-7

tafamidis meglumine

Purity: ≥98%

Molecular weight: 503.33g/mol

Ref: 54-BUP13508

tafamidis meglumine

CAS: 951395-08-7

Tafamidis meglumine (Fx-1006A) is a Potent and Selective Transthyretin Kinetic Stabilizer That Inhibits the Amyloid Cascade

Formula: C₂₁H₂₄Cl₂N₂O₈

Purity: 97.89% - 99.98%

Color and Shape: Solid

Molecular weight: 503.33

Ref: TM-T7582

Tafamidis Meglumine

CAS: 951395-08-7

Formula: C₁₄H₇Cl₂NO₃·C₇H₁₇NO₅

Color and Shape: Neat

Molecular weight: 308.11 + 195.22

Ref: TR-T223615

Tafamidis Meglumine

CAS: 951395-08-7

Formula: C₁₄H₇Cl₂NO₃C₇H₁₇NO₅

Molecular weight: 308.1 : 195.2

Ref: ST-EA-CP-T108001