CAS 951792-83-9

L-Valine, S-[1-[[trans-4-[[[[trans-4-[[[(4S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-9-yl]oxy]carbonyl]cyclohexyl]methyl]amino]carbonyl]cyclohexyl]methyl]-2,5-dioxo-3-pyrrolidinyl]-L-cysteinyl-L-valyl-L-lysyl-L-arginylglycyl-L-leucyl-L-lysyl-L-leucyl-L-arginyl-L-histidyl-L-valyl-L-arginyl-L-prolyl-L-arginyl-L-valyl-L-threonyl-L-arginyl-L-methionyl-L-α-aspartyl-

Description:

The chemical substance known as L-Valine, S-[1-[[trans-4-[[[[trans-4-[[[(4S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-9-yl]oxy]carbonyl]cyclohexyl]methyl]amino]carbonyl]cyclohexyl]methyl]-2,5-dioxo-3-pyrrolidinyl]-L-cysteinyl-L-valyl-L-lysyl-L-arginylglycyl-L-leucyl-L-lysyl-L-leucyl-L-arginyl-L-histidyl-L-valyl-L-arginyl-L-prolyl-L-arginyl-L-valyl-L-threonyl-L-arginyl-L-methionyl-L-α-aspartyl- is a complex peptide with a long chain of amino acids, including L-valine, L-cysteine, L-lysine, and L-arginine, among others. This compound features multiple functional groups, including amine, carboxylic acid, and hydroxyl groups, contributing to its potential biological activity. Its intricate structure suggests it may have specific interactions with biological targets, possibly influencing protein synthesis or cellular signaling pathways. The presence of cyclic structures and various stereocenters indicates that it may exhibit chiral properties, which can affect its pharmacokinetics and pharmacodynamics. Overall, this substance is likely to be of interest in medicinal chemistry and biochemistry for its potential therapeutic applications.

Formula: C₁₄₅H₂₃₃N₄₃O₃₃S₂

Synonyms:

• L-Valine, S-[1-[[trans-4-[[[[trans-4-[[[(4S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl]oxy]carbonyl]cyclohexyl]methyl]amino]carbonyl]cyclohexyl]methyl]-2,5-dioxo-3-pyrrolidinyl]-L-cysteinyl-L-valyl-L-lysyl-L-arginylglycyl-L-leucyl-L-lys...
• L-Valine, S-[1-[[trans-4-[[[[trans-4-[[[(4S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-9-yl]oxy]carbonyl]cyclohexyl]methyl]amino]carbonyl]cyclohexyl]methyl]-2,5-dioxo-3-pyrrolidinyl]-L-cysteinyl-L-valyl-L-lysyl-L-arginylglycyl-L-leucyl-L-lysyl-L-leucyl-L-arginyl-L-histidyl-L-valyl-L-arginyl-L-prolyl-L-arginyl-L-valyl-L-threonyl-L-arginyl-L-methionyl-L-α-aspartyl-

DTS-108

CAS: 951792-83-9

DTS-108 is a prodrug of SN38 (a topoisomerase I inhibitor). It is a conjugate formed by linking SN38 to a human oligopeptide through an esterase-sensitive crosslinker. DTS-108 exhibits anticancer activity against colorectal cancer, lung cancer, and breast cancer.

Formula: C₁₄₅H₂₃₃N₄₃O₃₃S₂

Color and Shape: Solid

Molecular weight: 3170.8

Ref: TM-T203287