CAS 952651-49-9

3',5'-Di-O-benzoyl-2'-deoxy-2'-fluoro-5-fluoro-arabinouridine

Description:

3',5'-Di-O-benzoyl-2'-deoxy-2'-fluoro-5-fluoro-arabinouridine is a modified nucleoside that exhibits unique structural and chemical characteristics. This compound features a ribonucleoside backbone with specific substitutions at the 2' and 5' positions, where fluorine atoms replace hydrogen atoms, enhancing its stability and potentially altering its biological activity. The presence of benzoyl groups at the 3' and 5' positions contributes to its lipophilicity, which can influence its interaction with biological membranes and nucleic acid targets. This compound is of interest in medicinal chemistry and pharmaceutical research, particularly for its potential applications in antiviral therapies and as a tool in nucleic acid research. Its modifications may enhance binding affinity to specific enzymes or receptors, making it a candidate for further investigation in drug development. Additionally, the fluorinated structure may improve metabolic stability, allowing for prolonged activity in biological systems. Overall, 3',5'-Di-O-benzoyl-2'-deoxy-2'-fluoro-5-fluoro-arabinouridine represents a significant modification of natural nucleosides, with implications for therapeutic applications.

Formula: C₂₃H₁₈F₂N₂O₇

Synonyms:

• 3',5'-Di-O-benzoyl-2'-deoxy-2'-fluoro-5-fluoro-arabinouridine
• [(2R,3R,4S,5R)-3-benzoyloxy-4-fluoro-5-(5-fluoro-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl benzoate
• 1-(3,5-DI-O-BENZOYL-2-DEOXY-2-FLUORO-BETA-D-ARABINOFURANOSYL)-5-FLUORO-2,4(1H,3H)-PYRIMIDINEDIONE