CAS 952654-62-5

(3R,4R,5R,6R)-6-[4-[(4-fluorophenyl)methylcarbamoyl]-1-methyl-2-[1-methyl-1-[(5-methyl-1,3,4-oxadiazole-2-carbonyl)amino]ethyl]-6-oxo-pyrimidin-5-yl]oxy-3,4,5-trihydroxy-tetrahydropyran-2-carboxylic acid

Description:

The chemical substance with the name "(3R,4R,5R,6R)-6-[4-[(4-fluorophenyl)methylcarbamoyl]-1-methyl-2-[1-methyl-1-[(5-methyl-1,3,4-oxadiazole-2-carbonyl)amino]ethyl]-6-oxo-pyrimidin-5-yl]oxy-3,4,5-trihydroxy-tetrahydropyran-2-carboxylic acid" and CAS number "952654-62-5" is a complex organic compound characterized by its multi-functional groups and stereochemistry. It features a tetrahydropyran ring with multiple hydroxyl groups, indicating potential for hydrogen bonding and solubility in polar solvents. The presence of a pyrimidine moiety suggests biological activity, possibly as an inhibitor or modulator in biochemical pathways. The fluorophenyl and oxadiazole substituents may enhance its pharmacological properties, such as selectivity and potency. The compound's stereochemistry, denoted by the (3R,4R,5R,6R) configuration, implies specific spatial arrangements that can significantly influence its interaction with biological targets. Overall, this substance may have applications in medicinal chemistry, particularly in the development of therapeutics targeting specific diseases or conditions. Further studies would be necessary to elucidate its full biological profile and potential uses.

Formula: C₂₆H₂₉FN₆O₁₁

InChI: InChI=1/C26H29FN6O11/c1-10-31-32-21(42-10)20(38)30-26(2,3)25-29-13(19(37)28-9-11-5-7-12(27)8-6-11)17(22(39)33(25)4)43-24-16(36)14(34)15(35)18(44-24)23(40)41/h5-8,14-16,18,24,34-36H,9H2,1-4H3,(H,28,37)(H,30,38)(H,40,41)/t14-,15-,16-,18?,24+/m1/s1

Raltegravir Glucuronide

CAS: 952654-62-5

Formula: C₂₆H₂₉FN₆O₁₁

Color and Shape: White To Off-White Solid

Molecular weight: 620.55

Ref: 4Z-R-243

Raltegravir b-D-glucuronide

CAS: 952654-62-5

Ref: 7W-GC7918

Raltegravir beta-D-glucuronide

CAS: 952654-62-5

Applications A metabolite of Raltegravir.
References Bosma, P., et al.: J. Biol. Chem., 269, 17960 (1994), Richman, D., et al.: Nature, 410, 995 (2001), Williams, J., et al.: Drug Metab. Dispos., 32, 1201 (2004), Miners, J., et al.: Biochem. Pharmacol., 71, 1531 (2006),

Formula: C₂₆H₂₉FN₆O₁₁

Color and Shape: Neat

Molecular weight: 620.54

Ref: TR-R100310

Raltegravir-d3 b-D-Glucuronide (>90%)

Controlled Product

CAS: 952654-62-5

Applications A labelled metabolite of Raltegravir.
References Bosma, P., et al.: J. Biol. Chem., 269, 17960 (1994) , Richman, D., et al.: Nature, 410, 995 (2001), Williams, J., et al.: Drug Metab. Dispos., 32, 1201 (2004), Miners, J., et al.: Biochem. Pharmacol., 71, 1531 (2006),

Formula: C₂₆H₂₆D₃FN₆O₁₁

Purity: >90%

Color and Shape: Neat

Molecular weight: 623.56

Ref: TR-R100312

Raltegravir b-D-glucuronide

CAS: 952654-62-5

Raltegravir b-D-glucuronide is a synthetic, fluorinated analog of raltegravir. It is a potent HIV-1 integrase inhibitor that has been shown to be active against the majority of HIV-1 strains. Raltegravir b-D-glucuronide is less potent than the parent compound and exhibits reduced antiviral activity in vitro. Raltegravir b-D-glucuronide is metabolized to raltegravir and eliminated in urine as the glucuronide conjugate.

Formula: C₂₆H₂₉FN₆O₁₁

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 620.54 g/mol

Ref: 3D-MR09516

Raltegravir β-D-Glucuronide

CAS: 952654-62-5

Formula: C₂₆H₂₉FN₆O₁₁

Molecular weight: 620.55

Ref: ST-EA-CP-R6020