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CAS 95399-71-6

:

Fosinoprilat

Description:
Fosinoprilat is the active metabolite of fosinopril, an angiotensin-converting enzyme (ACE) inhibitor used primarily in the treatment of hypertension and heart failure. It is characterized by its ability to inhibit the conversion of angiotensin I to angiotensin II, leading to vasodilation and reduced blood pressure. Fosinoprilat is a prodrug that is converted in the body to its active form, which has a long half-life, allowing for once-daily dosing. The substance is typically administered orally and is known for its favorable pharmacokinetic profile, including a dual elimination pathway via both renal and hepatic routes. Fosinoprilat is also notable for its ability to improve cardiovascular outcomes and is often used in combination with other antihypertensive agents. Its chemical structure includes a phosphinic acid group, which contributes to its unique mechanism of action compared to other ACE inhibitors. As with any medication, potential side effects may include cough, hyperkalemia, and renal impairment, necessitating monitoring during treatment.
Formula:C23H34NO5P
InChI:InChI=1/C23H34NO5P/c25-22(17-30(28,29)14-8-7-11-18-9-3-1-4-10-18)24-16-20(15-21(24)23(26)27)19-12-5-2-6-13-19/h1,3-4,9-10,19-21H,2,5-8,11-17H2,(H,26,27)(H,28,29)/t20-,21+/m1/s1
InChI key:InChIKey=WOIWWYDXDVSWAZ-RTWAWAEBSA-N
SMILES:C(CP(CCCCC1=CC=CC=C1)(=O)O)(=O)N2C[C@@H](C[C@H]2C(O)=O)C3CCCCC3
Synonyms:
  • (4S)-4-Cyclohexyl-1-((hydroxy(4-phenylbutyl)phosphinyl)acetyl)-L-proline
  • (4S)-4-Cyclohexyl-1-[2-[hydroxy(4-phenylbutyl)phosphinyl]acetyl]-<span class="text-smallcaps">L</span>-proline
  • (4S)-4-cyclohexyl-1-{[hydroxy(4-phenylbutyl)phosphoryl]acetyl}-L-proline
  • <span class="text-smallcaps">L</span>-Proline, 4-cyclohexyl-1-[2-[hydroxy(4-phenylbutyl)phosphinyl]acetyl]-, (4S)-
  • <span class="text-smallcaps">L</span>-Proline, 4-cyclohexyl-1-[[hydroxy(4-phenylbutyl)phosphinyl]acetyl]-, (4S)-
  • <span class="text-smallcaps">L</span>-Proline, 4-cyclohexyl-1-[[hydroxy(4-phenylbutyl)phosphinyl]acetyl]-, trans-
  • Fosfenopril
  • Fosinopril diacid
  • Fosinoprilat [USAN:INN]
  • Fosinoprilatum
  • See more synonyms
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