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CAS 956103-76-7

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Florbetapir

Description:
Florbetapir, with the CAS number 956103-76-7, is a radiopharmaceutical compound primarily used in positron emission tomography (PET) imaging to detect amyloid plaques in the brain, which are associated with Alzheimer's disease. It is a derivative of the stilbene class and is characterized by its ability to bind selectively to amyloid-beta aggregates. Florbetapir is typically administered as a radiolabeled tracer, allowing for visualization of amyloid deposition in vivo. The compound has a relatively low molecular weight and is designed to cross the blood-brain barrier effectively. Its pharmacokinetics involve rapid distribution in the brain, followed by a gradual clearance, which is essential for accurate imaging. Safety profiles indicate that it is generally well-tolerated, although, like all radiopharmaceuticals, it requires careful handling and administration due to its radioactive properties. Overall, Florbetapir plays a crucial role in the early diagnosis and management of Alzheimer's disease, contributing to better patient outcomes through timely intervention.
Formula:C20H25FN2O3
InChI:InChI=1S/C20H25FN2O3/c1-22-19-7-4-17(5-8-19)2-3-18-6-9-20(23-16-18)26-15-14-25-13-12-24-11-10-21/h2-9,16,22H,10-15H2,1H3/b3-2+/i21-1
InChI key:InChIKey=YNDIAUKFXKEXSV-CRYLGTRXSA-N
SMILES:C(=C/C1=CC=C(NC)C=C1)\C=2C=CC(OCCOCCOCC[18F])=NC2
Synonyms:
  • 4-[(1E)-2-[6-[2-[2-[2-(Fluoro-18F)ethoxy]ethoxy]ethoxy]-3-pyridinyl]ethenyl]-N-methylbenzenamine
  • 18F-AV45
  • Benzenamine, 4-[(1E)-2-[6-[2-[2-[2-(fluoro-18F)ethoxy]ethoxy]ethoxy]-3-pyridinyl]ethenyl]-N-methyl-
  • Florbetapir F 18
  • Florbetapir (18F)
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