CAS: 956697-53-3 - LDE225

Formula: C₂₆H₂₆F₃N₃O₃

InChI: InChI=1/C26H26F3N3O3/c1-16-14-32(15-17(2)34-16)24-12-9-20(13-30-24)31-25(33)23-6-4-5-22(18(23)3)19-7-10-21(11-8-19)35-26(27,28)29/h4-13,16-17H,14-15H2,1-3H3,(H,31,33)/t16-,17+

InChI key: InChIKey=VZZJRYRQSPEMTK-CALCHBBNNA-N

SMILES: O=C(NC1=CN=C(C=C1)N2CC(OC(C)C2)C)C3=CC=CC(C4=CC=C(OC(F)(F)F)C=C4)=C3C

Synonyms:

• Nvp-Lde225
• Nvp-lde 225
• Lde-225
• Lde225(Nvp-Lde225)
• LDE225 (NVP-LDE225, Erismodegib)
• N-[6-[(2S,6R)-2,6-Dimethylmorpholin-4-yl]-3-pyridyl]-2-methyl-3-[4-(trifluoromethoxy)phenyl]benzamide
• N-{6-[(3R,4R,5S)-3-Hydroxy-4,5-dimethylpiperidin-1-yl]pyridin-3-yl}-2-methyl-3-[4-(trifluoromethoxy)phenyl]benzamide
• N-{6-[(2R,6S)-2,6-Dimethylmorpholin-4-yl]pyridin-3-yl}-2-methyl-3-[4-(trifluoromethoxy)phenyl]benzamide
• N-[6-[(2R,6S)-2,6-Dimethyl-4-morpholinyl]-3-pyridinyl]-2-methyl-4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-carboxamide
• N-(6-((2S,6R)-2,6-dimethylmorpholino)pyridin-3-yl)-2-methyl-4'-(trifluoromethoxy)biphenyl-3-carboxamide
• Erismodegib
• rel-N-[6-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-3-pyridinyl]-2-methyl-4'-(trifluoromethoxy)-1,1'-biphenyl]-3-carboxamide
• [1,1'-Biphenyl]-3-carboxamide, N-[6-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-3-pyridinyl]-2-methyl-4'-(trifluoromethoxy)-, rel-
• Sonidegib

Erismodegib

CAS: 956697-53-3

• Formula: C₂₆H₂₆F₃N₃O₃
• Purity: 99.93% (Typical Value in Batch COA)
• Color and Shape: white solid
• Molecular weight: 485.50g/mol

Erismodegib Diphosphate

CAS: 1218778-77-8 956697-53-3

• Formula: C₂₆H₂₆F₃N₃O₃H₃O₄P
• Molecular weight: 485.51 2*97.99

Erismodegib-d4

CAS: 956697-53-3

• Formula: C₂₆H₂₂D₄F₃N₃O₃
• Molecular weight: 489.53

Sonidegib

CAS: 956697-53-3

Sonidegib (Erismodegib), a Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 of 1.3 nM …

• Formula: C₂₆H₂₆F₃N₃O₃
• Purity: 99.97%
• Color and Shape: Solid
• Molecular weight: 485.5

Erismodegib

CAS: 956697-53-3

Antagonist of Smoothened GPCR; antineoplastic

• Formula: C₂₆H₂₆F₃N₃O₃
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 485.5 g/mol

Erismodegib

CAS: 956697-53-3

Applications A potent, selective and orally bioavailable Smoothened (SMO) antagonist; it inhibits hedgehog (Hh) signaling …

• Formula: C₂₆H₂₆F₃N₃O₃
• Color and Shape: Light Purple Solid
• Molecular weight: 485.50

Erismodegib-d4

CAS: 956697-53-3

• Formula: C₂₆H₂₂D₄F₃N₃O₃
• Color and Shape: White to Off-White Solid
• Molecular weight: 489.523