CAS 957-75-5

5-Bromouridine

Description:

5-Bromouridine is a nucleoside analog of uridine, characterized by the presence of a bromine atom at the 5-position of the uracil base. Its molecular formula is C₁₁H₁₄BrN₃O₅, and it has a molecular weight that reflects its structure. This compound is known for its role in biochemical research, particularly in studies related to RNA synthesis and antiviral activity. 5-Bromouridine can be incorporated into RNA in place of uridine, which can affect the function and stability of RNA molecules. It exhibits properties typical of nucleosides, including the ability to form hydrogen bonds and participate in base pairing. Additionally, 5-Bromouridine has been investigated for its potential therapeutic applications, particularly in the context of viral infections and cancer treatment, due to its ability to interfere with nucleic acid metabolism. Its solubility and stability in various solvents make it a useful compound in laboratory settings for studying nucleic acid interactions and functions.

Formula: C₉H₁₁BrN₂O₆

InChI: InChI=1S/C9H11BrN2O6/c10-3-1-12(9(17)11-7(3)16)8-6(15)5(14)4(2-13)18-8/h1,4-6,8,13-15H,2H2,(H,11,16,17)/t4-,5-,6-,8-/m1/s1

InChI key: InChIKey=AGFIRQJZCNVMCW-UAKXSSHOSA-N

SMILES: O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C(=O)NC(=O)C(Br)=C2

Synonyms:

• 1-beta-Ribofuranosyl-5-bromo-uracil
• 4-Amino-5-bromo-1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
• 5-Bromouracil ribonucleoside
• 5-bromo-1-pentofuranosylpyrimidine-2,4(1H,3H)-dione
• Brn 0033664
• Nsc 38296
• Uridine, 5-bromo-
• 5-Bromouridine
• 5-24-06-00337 (Beilstein Handbook Reference)
• (-)-5-Bromouridine
• 5-Bromo-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
• 5-BrU
• 5-BROMOURIDINE (5-BROMOURACIL-1-β-D-RIBOFURANOSIDE: 5-BRU)
• 5-BROMO-URIDINE(5-BRU)
• 5-Bromo-D-uridine
• 5-bromouracil-1-β-d-ribofuranoside
• 5-BROMOURIDINE extrapure
• 5-Bromouridine, 99+%
• 5-Bromouracil-1-β-D-ribofuranoside, 5-Bromouridine
• 5-BROMOURACIL-1-BETA-D-RIBOFURANOSIDE
• 5-Bromouridine,98%

5-Bromouridine, 98%

CAS: 957-75-5

5-Bromouridine is often incorporated into RNA in order to detect immunocytochemically and analyzed by cytometry. It possesses anti-viral activity and inhibits the activity of viruses such as human immunodeficiency virus. This Thermo Scientific Chemicals brand product was originally part of the Alfa

Formula: C₉H₁₁BrN₂O₆

Purity: 98%

Color and Shape: White, Powder

Molecular weight: 323.10

Ref: 02-A18507

5-Bromo-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

CAS: 957-75-5

Formula: C₉H₁₁BrN₂O₆

Purity: 97%

Color and Shape: Solid

Molecular weight: 323.0974

Ref: IN-DA006AZM

5-Bromouridine

CAS: 957-75-5

5-Bromouridine

Purity: 98%

Molecular weight: 323.10g/mol

Ref: 54-OR1011840

5-Bromouridine

CAS: 957-75-5

Formula: C₉H₁₁BrN₂O₆

Purity: >99.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 323.10

Ref: 3B-B0666

5-Bromouridine

CAS: 957-75-5

Formula: C₉H₁₁BrN₂O₆

Molecular weight: 323.10

Ref: 7W-GN9949

5-Bromouridine

CAS: 957-75-5

5-Bromouridine is a antitumor uracil derivative that induces apoptosis in cancer cells by inhibiting DNA synthesis and is also a marker for DNA and RNA.

Formula: C₉H₁₁BrN₂O₆

Purity: 99.89%

Color and Shape: White Powder

Molecular weight: 323.1

Ref: TM-T36894

5-Bromouridine

CAS: 957-75-5

5-Bromouridine is an energy-related metabolite that is a precursor of uridine. It is a nucleotide base that is incorporated into DNA during DNA replication. 5-Bromouridine has been shown to have radiation resistance and high resistance to viral life. It also binds to the nuclear DNA in cells, where it can act as a transcriptional regulator. 5-Bromouridine is used in the treatment of malignant brain tumors, where it can inhibit tumor growth by binding to the dna of cancer cells and preventing the synthesis of proteins required for cell division. 5-Bromouridine binds with high affinity to basic fibroblast, which may be related to its effects on cancer cells.

Formula: C₉H₁₁BrN₂O₆

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 323.1 g/mol

Ref: 3D-NB03843

5-Bromouridine

CAS: 957-75-5

Formula: C₉H₁₁BrN₂O₆

Purity: 97%

Color and Shape: Solid

Molecular weight: 323.099

Ref: 10-F050870

5-Bromouridine extrapure, 99%

CAS: 957-75-5

Formula: C₉H₁₁BrN₂O₆

Purity: min. 99%

Color and Shape: White to off-white, Powder or crystals

Molecular weight: 323.11

Ref: SR-12211

5-Bromouridine

Controlled Product

CAS: 957-75-5

Applications 5-Bromouridine is a uridine (U829910) derivative and is often incorporated into RNA in order to detect immunocytochemically and analyzed by cytometry.
References Kramer, K., et al.: Int. J. Mass. Spect., 304, 184 (2011); Denifi, S., et al.: Euro. Phys. J. Atomic. Molec. Optical. Phys., 35, 391 (2005);

Formula: C₉H₁₁BrN₂O₆

Color and Shape: Neat

Molecular weight: 323.1

Ref: TR-B688960