CAS 957054-30-7

Pictilisib

Description:

Pictilisib, with the CAS number 957054-30-7, is a small molecule inhibitor that primarily targets phosphatidylinositol 3-kinase (PI3K), a key enzyme involved in various cellular processes, including growth, proliferation, and survival. It is classified as a selective inhibitor, particularly effective against the alpha and delta isoforms of PI3K. Pictilisib has garnered attention in cancer research due to its potential therapeutic applications, especially in tumors with aberrant PI3K signaling pathways. The compound is typically administered in a clinical setting and has been evaluated in various cancer types, including breast cancer and other solid tumors. Its mechanism of action involves disrupting the PI3K signaling cascade, which can lead to reduced tumor cell proliferation and increased apoptosis. Pictilisib is often studied in combination with other therapies to enhance its efficacy and overcome resistance mechanisms. As with many investigational drugs, its safety profile and pharmacokinetics are subjects of ongoing research to optimize its clinical use.

Formula: C₂₃H₂₇N₇O₃S₂

InChI: InChI=1S/C23H27N7O3S2/c1-35(31,32)30-7-5-28(6-8-30)15-16-13-20-21(34-16)23(29-9-11-33-12-10-29)26-22(25-20)17-3-2-4-19-18(17)14-24-27-19/h2-4,13-14H,5-12,15H2,1H3,(H,24,27)

InChI key: InChIKey=LHNIIDJUOCFXAP-UHFFFAOYSA-N

SMILES: C(C=1SC2=C(N=C(N=C2C1)C3=C4C(=CC=C3)NN=C4)N5CCOCC5)N6CCN(S(C)(=O)=O)CC6

Synonyms:

• 2-(1H-Indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine
• 2-(1H-Indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)thieno[3,2-d]pyrimidine
• 4-[2-(1H-Indazol-4-yl)-6-[[4-(methylsulfonyl)piperazin-1-yl]methyl]thieno[3,2-d]pyrimidin-4-yl]morpholine
• Gdc 941
• Gdc-0941
• Gne 0941
• Pictilisib
• Thieno[3,2-d]pyrimidine, 2-(1H-indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)-

Pictilisib

CAS: 957054-30-7

Pictilisib

Purity: ≥98%

Molecular weight: 513.64g/mol

Ref: 54-BUP14431

Pictilisib (GDC-0941)

CAS: 957054-30-7

Formula: C₂₃H₂₇N₇O₃S₂

Color and Shape: Pale Yellow Solid

Molecular weight: 513.64

Ref: 4Z-P-268001

GDC-0941

CAS: 957054-30-7

Ref: 7W-GW4351

Pictilisib

CAS: 957054-30-7

Pictilisib (GDC-0941) (GDC-0941) is a potent pan inhibitor of class I catalytic subunits of PI3K (IC50s: 3/33/3/75 nM for p110α/β/δ/γ).

Formula: C₂₃H₂₇N₇O₃S₂

Purity: 98.69% - 99.97%

Color and Shape: Solid

Molecular weight: 513.64

Ref: TM-T1994

GDC 0941

CAS: 957054-30-7

Pan-class I phosphatidylinositide 3-kinase (PI3K) inhibitor (IC50 = 3, 33, 3 and 75 nM at catalytic subunits p110α, p110β, p110δ and p110γ respectively). Inhibits proliferation in several cancer cell lines, such as glioblastoma, breast and prostate cancer cells. Has synergistic anti-cancer effect in combination with MEK/ERK kinase inhibitor GDC-0973 (cobimetinib).

Formula: C₂₃H₂₇N₇O₃S₂

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 513.64 g/mol

Ref: 3D-FI32904

GDC-0941

Controlled Product

CAS: 957054-30-7

Applications GDC-0941 is a potent and selective oral inhibitor of the class I PI3K. GDC-0941 demonstrated broad spectrum of activity in breast, ovarian, lung, and prostate cancer models. Studies has also shown GDC-0941 may enhance anti-tumor activity of Docetaxel (D494420) in human breast cancer models. Potent PI3K inhibitor.
References Jeffrey J.W., et al.: Clinical. Cancer. Rsch., 10, 1078 (2012); Murray, J.M., et al.: J. Medn. Chem., 55, 7686 (2012);

Formula: C₂₃H₂₇N₇O₃S₂

Color and Shape: Neat

Molecular weight: 513.64

Ref: TR-G601510