CAS 957054-33-0

Thieno[3,2-d]pyrimidine, 2-(1H-indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)-, methanesulfonate (1:2)

Description:

Thieno[3,2-d]pyrimidine, 2-(1H-indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)-, methanesulfonate (1:2) is a complex organic compound characterized by its unique structural features, which include a thieno[3,2-d]pyrimidine core fused with an indazole moiety and substituted with a piperazine and morpholine group. This compound is typically utilized in pharmaceutical research, particularly in the development of potential therapeutic agents due to its bioactive properties. The presence of the methanesulfonate salt form enhances its solubility and stability, making it suitable for various biological assays. Its molecular structure suggests potential interactions with biological targets, which may include enzymes or receptors involved in disease pathways. The compound's synthesis and characterization involve advanced organic chemistry techniques, and it is subject to rigorous testing for efficacy and safety in preclinical studies. Overall, this compound exemplifies the intricate design often found in medicinal chemistry aimed at optimizing pharmacological profiles.

Formula: C₂₃H₂₇N₇O₃S₂·2CH₄O₃S

InChI: InChI=1S/C23H27N7O3S2.CH4O3S/c1-35(31,32)30-7-5-28(6-8-30)15-16-13-20-21(34-16)23(29-9-11-33-12-10-29)26-22(25-20)17-3-2-4-19-18(17)14-24-27-19;1-5(2,3)4/h2-4,13-14H,5-12,15H2,1H3,(H,24,27);1H3,(H,2,3,4)

InChI key: InChIKey=OZRVQTBMLHRDIR-UHFFFAOYSA-N

SMILES: C(C=1SC2=C(N=C(N=C2C1)C3=C4C(=CC=C3)NN=C4)N5CCOCC5)N6CCN(S(C)(=O)=O)CC6.S(C)(=O)(=O)O

Synonyms:

• 2-(1H-Indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine
• 2-(1H-Indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)thieno[3,2-d]pyrimidine
• Gdc-0941
• Thieno[3,2-d]pyrimidine, 2-(1H-indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)-, methanesulfonate (1:2)

Pictilisib dimethanesulfonate

CAS: 957054-33-0

Pictilisib dimethanesulfonate (GDC-0941 2 MeSO3H salt) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest selectivity against p110β (11-fold) and

Formula: C₂₅H₃₅N₇O₉S₄

Purity: 99.63%

Color and Shape: Solid

Molecular weight: 705.85

Ref: TM-T11381

4-(2-(1H-Indazol-4-yl)-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)thieno[3,2-d]pyrimidin-4-yl)morpholine dimethanesulfonate

CAS: 957054-33-0

Formula: C₂₅H₃₅N₇O₉S₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 705.8469

Ref: IN-DA01CBDB

Pictilisib dimethanesulfonate

CAS: 957054-33-0

Pictilisib dimethanesulfonate

Purity: ≥98%

Molecular weight: 705.85g/mol

Ref: 54-BUP11383

GDC-0941 Bimesylate

CAS: 957054-33-0

Applications Potent inhibitor of Phosphatidylinositol 3-kinase (PI3K)

Formula: C₂₃H₂₇N₇O₃S₂·2(CH₄O₃S)

Color and Shape: Light Yellow Solid

Molecular weight: 705.85

Ref: TR-G300000

GDC 0941 bimesylate

CAS: 957054-33-0

Pan-PI3K inhibitor of class I catalytic subunits; anti-proliferative

Formula: C₂₅H₃₅N₇O₉S₄

Purity: Min. 95%

Molecular weight: 705.85 g/mol

Ref: 3D-FG23650