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CAS 95716-70-4

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Δ9,11-Eplerenone

Description:
Δ9,11-Eplerenone is a synthetic steroid compound that belongs to the class of mineralocorticoid receptor antagonists. It is primarily used in the treatment of conditions such as hypertension and heart failure, particularly in patients with left ventricular dysfunction following a myocardial infarction. The compound exhibits a high affinity for mineralocorticoid receptors, which allows it to effectively block the action of aldosterone, a hormone that regulates sodium and water balance in the body. Δ9,11-Eplerenone is characterized by its unique molecular structure, which includes a lactone ring and specific double bonds that contribute to its pharmacological properties. It is generally administered orally and is known for its relatively favorable side effect profile compared to other similar agents, such as spironolactone. The compound is metabolized in the liver, primarily through cytochrome P450 enzymes, and its elimination half-life allows for once-daily dosing in clinical practice. Overall, Δ9,11-Eplerenone plays a significant role in cardiovascular therapy by helping to manage fluid retention and reduce blood pressure.
Formula:C24H30O5
InChI:InChI=1S/C24H30O5/c1-22-8-4-15(25)12-14(22)13-16(21(27)28-3)20-17(22)5-9-23(2)18(20)6-10-24(23)11-7-19(26)29-24/h5,12,16,18,20H,4,6-11,13H2,1-3H3/t16-,18+,20-,22+,23+,24-/m1/s1
InChI key:InChIKey=GWEKWJOSBYDYDP-DPOGTSLVSA-N
SMILES:C[C@@]12[C@]3(CC[C@]1([C@]4(C(=CC2)[C@]5(C)C(C[C@H]4C(OC)=O)=CC(=O)CC5)[H])[H])OC(=O)CC3
Synonyms:
  • (7A,17A)-17-Hydroxy-3-Oxo-Pregna-4,9(11)-Diene-7,21-Dicarboxylicacid G-Lactone Methyl Ester
  • 7α-(Methoxycarbonyl)-9(11)<sup>Δ</sup>-canrenone
  • Eplerenone Intermediates
  • Eplerenone N-1
  • Pregna-4,9(11)-diene-7,21-dicarboxylic acid, 17-hydroxy-3-oxo-, γ-lactone, 7-methyl ester, (7α,17α)-
  • Pregna-4,9(11)-diene-7,21-dicarboxylicacid, 17-hydroxy-3-oxo-, g-lactone, 7-methyl ester, (7a,17a)-
  • Δ<sup>9,11</sup>-Eplerenone
  • Pregna-4,9(11)-diene-7,21-dicarboxylic acid, 17-hydroxy-3-oxo-, γ-lactone, methyl ester, (7α,17α)-
  • 7α-(Methoxycarbonyl)-9(11)Δ-canrenone
  • Δ9,11-Eplerenone
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