CAS 95729-65-0

Azetirelin

Description:

Azetirelin, with the CAS number 95729-65-0, is a synthetic peptide that functions as a thyrotropin-releasing hormone (TRH) analog. It is characterized by its ability to stimulate the release of thyroid-stimulating hormone (TSH) and prolactin from the anterior pituitary gland, thereby influencing thyroid function and metabolism. Azetirelin is typically utilized in research settings to explore its effects on thyroid regulation and potential therapeutic applications in conditions related to thyroid hormone imbalance. The compound is known for its relatively low molecular weight and specific structural features that enhance its biological activity compared to natural TRH. Its pharmacological profile includes a relatively short half-life, necessitating careful consideration in dosing regimens for experimental use. As with many peptides, stability and solubility can be influenced by environmental factors, making proper handling and storage essential for maintaining its efficacy. Overall, Azetirelin represents a valuable tool in endocrinological research, particularly in the study of thyroid disorders.

Formula: C₁₅H₂₀N₆O₄

InChI: InChI=1/C15H20N6O4/c16-13(23)11-2-1-3-21(11)15(25)10(4-8-6-17-7-18-8)20-14(24)9-5-12(22)19-9/h6-7,9-11H,1-5H2,(H2,16,23)(H,17,18)(H,19,22)(H,20,24)/t9-,10-,11-/m0/s1

SMILES: C1C[C@@H](C(=N)O)N(C1)C(=O)[C@H](Cc1cnc[nH]1)N=C([C@@H]1CC(=N1)O)O

Synonyms:

• Azetirelin [INN]
• (-)-N-(((2S)-4-Oxo-2-azetidinyl)carbonyl)-L-histidyl-L-prolinamide
• Azetirelina
• Azetirelina [INN-Spanish]
• Azetireline
• Azetireline [INN-French]
• Azetirelinum
• Azetirelinum [INN-Latin]
• Unii-70J5Awg54Q
• L-Prolinamide, N-((4-oxo-2-azetidinyl)carbonyl)-L-histidyl-, (S)-
• N-{[(2S)-4-oxoazetidin-2-yl]carbonyl}-L-histidyl-L-prolinamide

Azetirelin

CAS: 95729-65-0

Azetirelin

Purity: ≥98%

Molecular weight: 348.36g/mol

Ref: 54-BUP13932

Azetirelin (~85%)

Controlled Product

CAS: 95729-65-0

Applications Azetirelin is a thyrotropin-releasing hormone (TRH) analogue. It demonstrated neuroprotective activity in rats.
References Behrmann, D., et al.: Exp. Neurol., 126, 61 (1994); Faden, A., et al.: J. Cereb. Blood Flow Metab., 23, 342 (2003);

Formula: C₁₅H₂₀N₆O₄

Purity: ~85%

Color and Shape: Neat

Molecular weight: 348.36

Ref: TR-A817605

Azetirelin

CAS: 95729-65-0

Azetirelin is a peptide that binds to the receptors of ion channels. It has been used as a research tool to study the function of ion channels in various cell types and tissues. Azetirelin has been shown to activate certain ion channels, including calcium-activated potassium channels and nicotinic acetylcholine receptors. This peptide also inhibits voltage-gated sodium channels and calcium-activated potassium channels.

Formula: C₁₅H₂₀N₆O₄

Purity: Min. 95%

Molecular weight: 348.36 g/mol

Ref: 3D-VDA72965

Azetirelin

CAS: 95729-65-0

Azetirelin, as a TRH analog, has a more potent effect than TRH on the central nervous system.

Formula: C₁₅H₂₀N₆O₄

Purity: 99.72%

Color and Shape: Solid

Molecular weight: 348.36

Ref: TM-T30269