CAS 95751-30-7

Charybdotoxin

Description:

Charybdotoxin is a peptide toxin derived from the venom of the Eastern green mamba snake (Dendroaspis angusticeps) and is classified as a member of the scorpion toxin family. It is known for its ability to selectively block certain types of potassium channels, particularly the voltage-gated potassium channels, which play a crucial role in regulating neuronal excitability and muscle contraction. The molecular structure of charybdotoxin consists of a relatively small peptide chain, typically comprising around 37 amino acids, and it exhibits a characteristic three-dimensional conformation stabilized by disulfide bonds. This toxin has garnered interest in pharmacological research due to its potential applications in studying ion channel function and its implications in neurobiology. Additionally, charybdotoxin has been investigated for its potential therapeutic uses, including in the treatment of certain neurological disorders. Its CAS number, 95751-30-7, is a unique identifier that facilitates the cataloging and referencing of this compound in scientific literature and databases.

Formula: C₁₇₆H₂₇₇N₅₇O₅₅S₇

Synonyms:

• 33,34,70,71,95,96-Hexathia-2,5,8,11,14,17,20,23,26,29,37,40,43,46,49,52,55,58,61,64,67,74,77,80,83,86,89,92-octacosaazatricyclo[34.32.25.413,79]heptanonacontane,cyclic peptide deriv.
• 36: PN: WO2006116156 SEQID: 36 claimed protein
• Charybdotoxin (Leiurus quinquestriatus hebraeus)
• Charybdotoxin (reduced),cyclic (7® 28),(13® 33),(17® 35)-tris(disulfide)

Charybdotoxin

CAS: 95751-30-7

Specific inhibitor of the big conductance Ca2+-activated K+ channel.

Formula: C₁₇₆H₂₇₇N₅₇O₅₅S₇

Purity: 98%

Color and Shape: Solid

Molecular weight: 4295.95

Ref: TM-TP2059

Charybdotoxin

CAS: 95751-30-7

Formula: C₁₇₆H₂₇₇N₅₇O₅₅S₇

Molecular weight: 4295.88

Ref: 7W-GL6735

Charybdotoxin

CAS: 95751-30-7

Charybdotoxin is a potent and selective ion channel inhibitor. It is a peptide that binds to the receptor site of the potassium channels that are found in nerve cells, blocking their activation. Charybdotoxin has also been shown to inhibit the activity of ligand-gated ion channels, such as acetylcholine receptors. This toxin has been used in research as a tool for studying protein interactions and has also been used in pharmacology as an experimental drug for treating hypertension.

Formula: C₁₇₆H₂₇₇N₅₇O₅₅S₇

Purity: Min. 95%

Molecular weight: 4,295.9 g/mol

Ref: 3D-PCB-4227-S

Charybdotoxin

CAS: 95751-30-7

Charybdotoxin is a peptide toxin that is found in scorpion venom. It acts as a potent inhibitor of the adenylyl cyclase, which is an enzyme that catalyzes the formation of cAMP from ATP. Charybdotoxin binds to the cavity of the enzyme and blocks access to ATP, preventing the accumulation of cAMP. This inhibition leads to a decrease in calcium ions in cells, and thus causes relaxation of smooth muscle tissue. Charybdotoxin has been shown to cause relaxation of bowel disease in mice by inhibiting contraction of intestinal muscle tissue. Charybdotoxin also has been shown to have therapeutic effects on pluripotent cells such as miapaca-2 cells by increasing their ability to form new blood vessels.

Formula: C₁₇₆H₂₇₇N₅₇O₅₅S₇

Purity: Min. 95%

Molecular weight: 4,295.9 g/mol

Ref: 3D-FC110443