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CAS 95753-55-2

:

fmoc-4-nitro-L-phenylalanine

Description:
Fmoc-4-nitro-L-phenylalanine is a derivative of the amino acid phenylalanine, characterized by the presence of a 4-nitro substituent on the aromatic ring and a fluorenylmethoxycarbonyl (Fmoc) protective group. This compound is commonly used in peptide synthesis, particularly in solid-phase peptide synthesis (SPPS), where the Fmoc group serves as a protective moiety for the amino group, allowing for selective coupling reactions. The nitro group introduces an electron-withdrawing effect, which can influence the reactivity and properties of the amino acid during synthesis. Fmoc-4-nitro-L-phenylalanine is typically a white to off-white solid and is soluble in organic solvents such as dimethylformamide (DMF) and dimethyl sulfoxide (DMSO), but less soluble in water. Its molecular structure contributes to its utility in the development of peptides with specific functionalities, and it can also serve as a building block in the synthesis of more complex biomolecules. Safety data should be consulted, as the nitro group can pose potential hazards.
Formula:C24H20N2O6
Synonyms:
  • Fmoc-L-4-Nitrophenylalanine
  • Fmoc-Phe(4-NO2)-OH
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