CAS 957881-03-7

Barasertib

Description:

Barasertib, with the CAS number 957881-03-7, is a small molecule inhibitor primarily targeting the Aurora kinase A and B, which are crucial for cell division and mitosis. This compound is classified as an antineoplastic agent, making it relevant in cancer research and treatment. Barasertib exhibits selective inhibition, which helps in disrupting the proliferation of cancer cells by interfering with their ability to properly undergo mitosis. Its chemical structure includes a pyrimidine core, contributing to its biological activity. The substance is typically administered in a clinical setting, often in combination with other therapies, to enhance its efficacy against various malignancies. Barasertib has undergone various clinical trials to evaluate its safety, tolerability, and effectiveness in treating specific types of cancer, particularly hematological malignancies. As with many targeted therapies, its use may be associated with specific side effects, necessitating careful monitoring during treatment. Overall, Barasertib represents a significant advancement in the development of targeted cancer therapies.

Formula: C₂₆H₃₀FN₇O₆P

InChI: InChI=1S/C26H31FN7O6P/c1-2-34(10-12-40-41(36,37)38)9-4-11-39-21-7-8-22-23(16-21)28-17-29-26(22)31-24-14-20(32-33-24)15-25(35)30-19-6-3-5-18(27)13-19/h3,5-8,13-14,16-17H,2,4,9-12,15H2,1H3,(H,30,35)(H2,36,37,38)(H2,28,29,31,32,33)

InChI key: InChIKey=GBJVVSCPOBPEIT-UHFFFAOYSA-N

SMILES: N(C=1C2=C(C=C(OCCCN(CCOP(=O)(O)O)CC)C=C2)N=CN1)C3=CC(CC(NC4=CC(F)=CC=C4)=O)=NN3

Synonyms:

• 5-[[7-[3-[Ethyl[2-(phosphonooxy)ethyl]amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-1H-pyrazole-3-acetamide
• AZD1152
• Barasertib
• 1H-Pyrazole-3-acetamide, 5-[[7-[3-[ethyl[2-(phosphonooxy)ethyl]amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-
• AZD 1152
• 2-(ETHYL(3-((4-((5-(2-((3-FLUOROPHENYL)AMINO)-2-OXOETHYL)-1H-PYRAZOL-3-YL)AMINO)QUINAZOLIN-7-YL)OXY)PROPYL)AMINO)ETHYL DIHYDROGEN PHOSPHATE
• 2-{Ethyl[3-({4-[(5-{2-[(3-fluorophenyl)amino]-2-oxoethyl}-1H-pyra zol-3-yl)amino]-7-quinazolinyl}oxy)propyl]amino}ethyl dihydrogen phosphate
• AZD1152 (Barasertib)
• 3-[[7-[3-[Ethyl[2-(phosphonooxy)ethyl]amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-1H-pyrazole-5-acetamide
• CS-383
• 2-{ethyl[3-({4-[(5-{2-[(3-fluorophenyl)amino]-2-oxoethyl}-1H-pyrazol-3-yl)amino]quinazolin-7-yl}oxy)proplyl]amino}ethyl dihydrogen phosphate

Azd1152 trifluoroacetic acid

CAS: 957881-03-7

Azd1152 trifluoroacetic acid is a heterocyclic compound that has been shown to have a potential therapeutic effect on skin cancer cells. It also inhibits the growth of solid tumours and inhibits the expression of stem cell factor, which may be due to its ability to bind with bromodomain. Azd1152 trifluoroacetic acid has been used in clinical studies for the treatment of hematologic disorders such as chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL). Azd1152 trifluoroacetic acid binds to histones H3 and H4 at their bromodomain, which may inhibit transcriptional activity by blocking the access of transcription factors. Azd1152 trifluoroacetic acid also inhibits the synthesis of DNA and RNA, which may contribute to its anti-cancer properties.

Formula: C₂₆H₃₁FN₇O₆P

Purity: Min. 95%

Molecular weight: 587.5 g/mol

Ref: 3D-HNB88103