CAS 95789-30-3

Cefotiam hexetil hydrochloride

Description:

Cefotiam hexetil hydrochloride is a semi-synthetic cephalosporin antibiotic that is primarily used for the treatment of various bacterial infections. It exhibits a broad spectrum of activity against both Gram-positive and Gram-negative bacteria, making it effective in treating respiratory, urinary tract, and skin infections. The compound is characterized by its stability against certain beta-lactamases, which are enzymes produced by some bacteria to resist antibiotic action. Cefotiam hexetil hydrochloride is typically administered orally and is known for its good absorption and bioavailability. Its mechanism of action involves inhibiting bacterial cell wall synthesis, leading to cell lysis and death. The substance is generally well-tolerated, though potential side effects may include gastrointestinal disturbances and allergic reactions. As with other antibiotics, it is crucial to use cefotiam hexetil hydrochloride judiciously to prevent the development of antibiotic resistance. Proper storage conditions and adherence to prescribed dosages are essential for maximizing its therapeutic efficacy.

Formula: C₂₇H₃₇N₉O₇S₃·2ClH

InChI: InChI=1S/C27H37N9O7S3.2ClH/c1-15(42-27(40)43-18-7-5-4-6-8-18)41-24(39)21-16(13-46-26-31-32-33-35(26)10-9-34(2)3)12-44-23-20(22(38)36(21)23)30-19(37)11-17-14-45-25(28)29-17;;/h14-15,18,20,23H,4-13H2,1-3H3,(H2,28,29)(H,30,37);2*1H/t15?,20-,23-;;/m1../s1

InChI key: InChIKey=FFSANQNELHESQJ-LWBICVDYSA-N

SMILES: C(OC(OC(OC1CCCCC1)=O)C)(=O)C=2N3[C@@]([C@H](NC(CC=4N=C(N)SC4)=O)C3=O)(SCC2CSC=5N(CCN(C)C)N=NN5)[H].Cl

Synonyms:

• 1-cyclohexyloxycarbonyloxyethyl (6R,7R)-7-[[2-(2-amino-1,3-thiazol-4-yl)acetyl]amino]-3-[[1-(2-dimethylaminoethyl)tetrazol-5-yl]sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate dihydrochloride
• 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2-amino-4-thiazolyl)acetyl)amino)-3-(((1-(2-(dimethylamino)ethyl)-1H-tetrazol-5-yl)thio)methyl)-8-oxo-, 1-(((cyclohexyloxy)carbonyl)oxy)ethyl ester, dihydrochloride, (6R-(6-alpha,7-beta))-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2- carboxylic acid,7-[[(2-amino-4-thiazolyl)- acetyl]amino]-3-[[[1-[2-(dimethylamino)- ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-,1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester,dihydrochloride,(6R,7R)-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-, 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester, dihydrochloride, [6R-(6α,7β)]-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[2-(2-amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-, 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester, hydrochloride (1:2), (6R,7R)-
• Cefotiam hexetil hydrochloride
• Cefotiam hexetil hydrochloride (JP14)
• Ctm-He
• Pansporin-T
• Pansporin-T (TN)
• Sce 2174

Cefotiam hexetil dihydrochloride

CAS: 95789-30-3

Formula: C₂₇H₃₉Cl₂N₉O₇S₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 768.7557

Ref: IN-DA00H7BY

Cefotiam Hexetil Hydrochloride

CAS: 95789-30-3

Cefotiam Hexetil Hydrochloride

Purity: ≥98%

Molecular weight: 768.77g/mol

Ref: 54-BUP06280

Cefotiam hexetil hydrochloride

CAS: 95789-30-3

Molecular weight: 768.76

Ref: 7W-GA3927

Cefotiam Hexetil Hydrochloride

CAS: 95789-30-3

Cefotiam Hydrochloride, a third-gen cephalosporin antibiotic, halts cell wall synthesis by inhibiting PBPs.

Formula: C₂₇H₃₇N₉O₇S₃·2ClH

Purity: >99.99%

Color and Shape: Solid

Molecular weight: 768.77

Ref: TM-T5024

Cefotiam Hexetil 2HCl

CAS: 95789-30-3

Formula: C₂₇H₃₇N₉O₇S₃·2HCl

Color and Shape: White To Off-White Solid

Molecular weight: 695.84 2*36.46

Ref: 4Z-C-10311

Cefotiam Hexetil Hydrochloride (mixture of Diastereomers)

Controlled Product

CAS: 95789-30-3

Applications A semi-synthetic cephalosporin antibiotic. Antibacterial.
References Goodhart, F., et al.: J. Pharamac. Sci., 62, 133 (1973), Maier, H., et al.: Arzneim.-Forsch., 42, 980 (1992),

Formula: C₂₇H₃₇N₉O₇S₃·2ClH

Color and Shape: Neat

Molecular weight: 768.76

Ref: TR-C243000